Bleeding Disorders - Symptoms - Causes - Types - Diagnosis - Treatment - FAQs
Bleeding disorder is an acquired or an inherited condition, which is characterized by excessive bleeding in the persons affected by the problem.
Bleeding disorder is an acquired or an inherited condition, which is characterized by excessive bleeding in the persons affected by the problem.
‘New study findings suggest the need for caution in prescribing direct oral anticoagulants in patients with CKD.’
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Given that approximately one-quarter of patients with atrial fibrillation have CKD, the real-world safety and effectiveness of direct oral anticoagulants in patients with atrial fibrillation across the spectrum of kidney function is of great public health importance. To investigate, Jung-Im Shin, MD, PhD (Johns Hopkins University) and her colleagues examined 2010-2017 information from the electronic health records of 3206 patients with atrial fibrillation who used direct oral anticoagulants and similar 3206 patients with atrial fibrillation who used the conventional anticoagulant warfarin. There were 1181 bleeding events and 466 ischemic strokes over 7391 person-years of follow-up. (A person-year is the number of years of follow-up multiplied by the number of people in the study.) In patients without CKD, the risk of bleeding and benefits of preventing ischemic stroke between direct oral anticoagulant and warfarin use were similar. On the other hand, patients with CKD who took direct oral anticoagulants had 23% higher risk of bleeding compared with those on warfarin, but similar benefits from prevention of ischemic stroke.
"Despite sparse evidence in safety and effectiveness of direct oral anticoagulants in CKD, we saw that prescription of direct oral anticoagulants in the CKD population increased substantially over time. We also found that direct oral anticoagulant use was linked with a higher risk of bleeding compared to warfarin use in patients with CKD." said Dr. Shin.
Quiz on Anticoagulants
Anticoagulants, commonly referred to as “blood thinners”, are medications that interfere with the body’s natural blood clotting mechanism. Anticoagulants are necessary if the patient has a deep vein thrombosis (“DVT”), a blood clot in a vital organ such as the heart, brain or liver, or if the patient has a condition that predisposes to blood clot formation such as atrial fibrillation or a hypercoaguability disorder. When a blood vessel is blocked by a clot, the individual could suffer a heart attack, pulmonary embolus or a stroke-all potentially fatal conditions. Anticoagulants also play a vital role in the preventative care of several health conditions. Take this quiz to find out how much you know about anticoagulant medication:
Anticoagulants, commonly referred to as “blood thinners”, are medications that interfere with the body’s natural blood clotting mechanism. Anticoagulants are necessary if the patient has a deep vein thrombosis (“DVT”), a blood clot in a vital organ such as the heart, brain or liver, or if the patient has a condition that predisposes to blood clot formation such as atrial fibrillation or a hypercoaguability disorder. When a blood vessel is blocked by a clot, the individual could suffer a heart attack, pulmonary embolus or a stroke-all potentially fatal conditions. Anticoagulants also play a vital role in the preventative care of several health conditions. Take this quiz to find out how much you know about anticoagulant medication:
Disclosures: G.C.A. is Chair of the US Food and Drug Administration's Peripheral and Central Nervous System Advisory Committee; has served as a paid consultant to IQVIA and serves on the Advisory Board of MesaRx Innovations; holds equity in Monument Analytics, a health care consultancy whose clients include the life sciences industry as well as plaintiffs in opioid litigation; and serves as a member of OptumRx's Pharmacy and Therapeutics Committee. This arrangement has been reviewed and approved by the Johns Hopkins Bloomberg School of Public Health.
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Animation On Key Hole Surgery for Kidney Stone Removal or Percutaneous Nephrolithotomy (PCNL)
Graphical explanation of stone removal from the kidney with a minimally invasive procedure called Percutaneous Nephrolithotomy. This is a major endoscopic procedure needing hospitalization.
Graphical explanation of stone removal from the kidney with a minimally invasive procedure called Percutaneous Nephrolithotomy. This is a major endoscopic procedure needing hospitalization.
Blood Thinners may Increase Stroke Risk in People with Kidney Disease
Blood thinners or anticoagulants taken by people over 65 years for irregular heartbeat can raise stroke risk if they have kidney disease.
Blood thinners or anticoagulants taken by people over 65 years for irregular heartbeat can raise stroke risk if they have kidney disease.
