About My Health Careers Internship MedBlogs Contact us
Medindia
LOGIN REGISTER
Advertisement

Opioid Dose Variability Could be a Risk Factor for Opioid Overdose

by Adeline Dorcas on April 20, 2019 at 4:05 PM
Font : A-A+

Opioid Dose Variability Could be a Risk Factor for Opioid Overdose

New study highlights that opioid dose variability may be a significant risk factor for opioid overdose. The findings of the study are published in the journal JAMA Network Open.

Patients prescribed opioid pain medications whose doses varied over time were 3 times more likely to experience an overdose than patients prescribed stable opioid doses, according to an observational study from Kaiser Permanente. The study also showed that patients who discontinued long-term opioid therapy for 3 or more months had half the risk of opioid overdose.

Advertisement


"Our study suggests that safely managing long-term opioid therapy is complex," said Ingrid Binswanger, MD, a senior investigator at Kaiser Permanente Institute for Health Research in Colorado and co-author of the study.

"This study suggests going up and down on opioid doses -- also called dose variability -- could present an increased risk of overdose," Dr. Binswanger said. "Through this study, we also found eventually discontinuing opioid therapy may prevent overdoses. With continued studies, we hope to find out how care providers can help patients with their pain without putting them at unnecessary risk due to rapid changes in their dose."
Advertisement

The 12-year study included more than 14,000 Kaiser Permanente members in Colorado who were prescribed long-term opioids. Researchers used electronic health records to track the history of patients to see if they had dose changes and overdoses from opioid pain medications and other opioid drugs.

The research team obtained a follow-up $2 million, 4-year grant from the National Institutes for Health. The study will look at how patients and doctors manage changes in opioid doses, including any long-term risks and benefits of discontinuing opioid pain medications.

"Kaiser Permanente, like many health care organizations across the country, has made significant changes to safely reduce opioid prescriptions for our members," said Jason Glanz, Ph.D., a senior investigator at the Institute for Health Research and co-author on the study.

"This study represents the first of many investigations that we plan to do on the topic," Dr. Glanz said. "Our goal is to help identify the most safe and effective approaches for managing long-term opioid therapy. We want to be able to minimize patients' pain and reduce their risk for overdose."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Emotional Healing
Psychosis Risk Related to Cat Parasite
Sedentary Behavior Precipitates Night-Time Hot Flashes
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cannabis Drug Abuse Amyotrophic Lateral Sclerosis (ALS) Drug Detox Painkiller Addiction Acute Coronary Syndrome Prescription Drug Abuse 

Recommended Reading
Investigational Drug Has Potential to Treat Opioid Withdrawal Symptoms
Rapastinel, the new experimental drug, could be useful to help manage opioid withdrawal during the ....
First Ever Smartphone App to Identify Opioid Overdose
First ever smartphone App dubbed SecondChance can accurately identify opioid overdose by monitoring ...
Does The One-Hour Discharge Rule After Opioid Overdose Still Stand?
After the naloxone, people with opioid overdose can be discharged, says the study. The one hour ......
New Model to Predict Opioid Overdose Risk Developed
New model predicts the risk of opioid overdose among Medicare beneficiaries with at least one ......
Acute Coronary Syndrome
Acute coronary syndrome (ACS) is a sudden, acute life-threatening condition caused by a dramatic red...
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or sub...
Drug Detox
Drug detoxification (or drug detox) is a process that helps drug addicts to give up drugs with less ...
Painkiller Addiction
Painkiller addiction is the use of prescription painkillers in a way not meant by the prescribing do...
Prescription Drug Abuse
Prescription drug abuse is consuming prescription medications in a way different from that as prescr...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use