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On-Off Body Switch Responsible For Burning Stored Fat Found!

by Sasikala Radhakrishnan on June 10, 2014 at 5:37 PM
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 On-Off Body Switch Responsible For Burning Stored Fat Found!

Scientists have succeeded in identifying an on-off switch that helps burn excess body fat.

A protein called GRB10 has been found by scientists to serve as an on-off stitch for MTORC1 signalling and the "beigeing" of fat.

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The researchers led by the School of Medicine at the University of Texas Health Science Center at San Antonio have also located a molecular pathway that regulates the conversion of unhealthy white fat into fat-burning beige fat.

Cold stress stimulates GRB10, which causes the body to burn energy, researchers said.

"We know that if we want to keep our body lean, we have to get rid of extra nutrients in the body, which means burning more energy," said senior author Feng Liu, professor of Pharmacology at the UT Health Science Center and director of the Metabolic Syndrome Research Center at Xiangya Second Hospital, Central South University, in Changsha, China.
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"Understanding how beigeing is controlled is so very important because if we can improve energy expenditure, we can reduce obesity," added Liu.

The vital controllers of energy metabolism are adipose (fat) tissues which are classified as white adipose tissue and brown adipose tissue.

Failure to burn white adipose tissue through exercises and/or other fat-burning methods leads to obesity and other metabolic diseases, such as diabetes type II.

"So finding a way to turn the white fat into beige and burn the energy that normally we store would have high therapeutic potential for the treatment of obesity and its related diseases. Dr liu has identified the pathway to do this," said co-author Lily Dong, professor of Cellular and Structural Biology at the UT Health Science Center.

The MTORC1 pathway also is responsible for aging, heart disease and cancer, and so identifying GRB10, the regulator of this pathway, should be very informative for researching other fields, Liu told.

The study is published in the journal 'Cell Metabolism.'

Source: Medindia
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