
Fish is a good source of omega-3 polyunsaturated fatty acids which may help to remove metabolites, including amyloid-beta peptides which is one of the factors that lead to Alzheimer's, finds a study conducted by researchers from the University of Macau.
To make this discovery, scientists first used transgenic fat-1 mice, which express high endogenous Omega-3 PUFAs in the brain, to investigate the effect of Omega-3 PUFAs on the clearance function of the glymphatic system.
Compared to the wild-type mice, the fat-1 mice with enriched endogenous Omega-3 PUFAs significantly promote the clearance function of the lymphatic system, including the amyloid-beta clearance from the brain.
"The brain is an extremely vascularised organ, while we might also bear in mind that Omega-3 fatty acids may impact neurons, glia, and astrocytes themselves," said Thoru Pederson, Editor-in-Chief of The FASEB Journal.
Omega-3 PUFAs help maintain the brain homeostasis, which may provide benefits in a number of neurological diseases, such as Alzheimer's disease, traumatic brain injury, and sleep impairment, among others.
Source: Medindia
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