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Omega-3-Fats in Fish May Prevent Alzheimer’s Disease

by Julia Samuel on October 31, 2016 at 5:15 PM
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Omega-3-Fats in Fish May Prevent Alzheimer’s Disease

Fish is a good source of omega-3 polyunsaturated fatty acids which may help to remove metabolites, including amyloid-beta peptides which is one of the factors that lead to Alzheimer's, finds a study conducted by researchers from the University of Macau.

To make this discovery, scientists first used transgenic fat-1 mice, which express high endogenous Omega-3 PUFAs in the brain, to investigate the effect of Omega-3 PUFAs on the clearance function of the glymphatic system.

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Compared to the wild-type mice, the fat-1 mice with enriched endogenous Omega-3 PUFAs significantly promote the clearance function of the lymphatic system, including the amyloid-beta clearance from the brain.

Wild-type mice were supplemented with fish oil, which contains high concentrations of Omega-3 PUFAs, and found that fish oil-supplemented mice also improved the clearance function of the glymphatic system compared to the control mice without fish oil supplementation.
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"The brain is an extremely vascularised organ, while we might also bear in mind that Omega-3 fatty acids may impact neurons, glia, and astrocytes themselves," said Thoru Pederson, Editor-in-Chief of The FASEB Journal.

Omega-3 PUFAs help maintain the brain homeostasis, which may provide benefits in a number of neurological diseases, such as Alzheimer's disease, traumatic brain injury, and sleep impairment, among others.

Source: Medindia
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