The U.S Food and Drug Administration (FDA) has granted approval for Ocaliva (obeticholic acid) for the treatment of primary biliary cholangitis (PBC).Primary biliary cholangitis is a rare chronic liver disease where the bile ducts in the liver become inflamed causing accumulation of bile, leading to scarring of liver or cirrhosis. The only approved treatment for PBC was ursodeoxycholic acid (UDCA) and patients who respond inadequately to this treatment can use Ocaliva in combination with UDCA. ‘The U.S. Food and Drug Administration granted accelerated approval for Ocaliva (obeticholic acid) for the treatment of primary biliary cholangitis (PBC).’ Ocaliva interacts with farnesoid X receptor (FXR), which plays a key role in bile acid regulation. By binding to this receptor Oclavia suppresses bile accumulation and increases the flow, leading to a reduction in bile levels in the liver. The drug was tested in 216 participants, wherein after one-year of follow-up, reductions in bile levels was higher among Ocaliva-treated participants compared to placebo-treated participants.Some of the side effects of Ocaliva include fatigue, abdominal pain, throat pain, dizziness and itching of the skin. Ocaliva is manufactured by New York-based Intercept Pharmaceuticals. Source: Medindia << Eliminating Dairy Products from Diet Does More Harm Than Goo... UK Receives Approval for Bionic Vision System Clinical Trial >> Recommended Reading New Treatment Provides Hope for Liver Disease Sufferers Norursodeoxycholic acid provided a safe and effective option for patients with primary sclerosing cholangitis and the treatment warrants further investigation. READ MORE Digestive Hormone 'Secretin' Has an Important Role In Chronic Liver Diseases High levels of a digestive hormone called secretin may play an important role in the management of certain chronic liver diseases. READ MORE Alcohol Ups Liver Damage in People With Hepatitis C Alcohol promotes faster development of fibrosis and progression to cirrhosis in people with hepatitis C, making drinking a dangerous and often deadly activity. READ MORE Treating Hepatitis C at Earlier Stage is Cheaper and Could Save Lives Treating hepatitis C patients could save $800 billion in the next 20 years and free up treatment for thousands of people with other liver diseases. READ MORE Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Biliary Cirrhosis Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Hearing Loss Calculator Calculate Ideal Weight for Infants Noscaphene (Noscapine) More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseBiliary CirrhosisMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?