Their initial results confirmed this hypothesis: In obese and lean mice that ate the same diet, tumors grew much faster in obese mice than they did in lean mice. The researchers also observed that there were far more white adipose tissue cells (called adipose stromal cells) in obese mice than in lean mice and thus turned their focus on the role of these cells.
Detailed analyses indicated cancer induced mobilization of adipose stromal cells into the circulation. Once in the tumors, some of these cells developed into fat cells, while others were incorporated into tumor-associated blood vessels.
Tumor-associated blood vessels support tumor growth by bringing in oxygen and nutrients vital for cancer cell survival and proliferation. Kolonin noted that the ability of adipose stromal cells to contribute to the formation of tumor-associated blood vessels is likely one of the main reasons that the excess of these cells in tumors was associated with increased malignant cell proliferation and tumor growth.
"Our data provide the first in vivo evidence of recruitment of cells from endogenous fat tissue to tumors," said Kolonin. "The fact that these cells are present in tumors is still an emerging concept. We have shown that not only are they present, but they are also functional and affect tumor growth. Identifying the signals that cause these cells to be recruited to tumors and finding ways to block them might provide a new avenue of cancer treatment."
Source: Newswise
