About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Obesity Promotes Tumor Growth: Study

by Sheela Philomena on October 15, 2012 at 10:51 AM
Font : A-A+

 Obesity Promotes Tumor Growth: Study

Recent studies have established an association between obesity and cancer incidence. Researchers have identified why obese patients with cancer often have a poorer prognosis compared with those who are lean. The potential explanation is based on data reported in Cancer Research, a journal of the American Association for Cancer Research.

Kolonin and his colleagues evaluated how obesity promotes cancer progression. "Our earlier studies led us to hypothesize that fat tissue called white adipose tissue, which is the fat tissue that expands in individuals who are obese, is itself directly involved and that it is not just diet and lifestyle that are important," he said.

Advertisement

Their initial results confirmed this hypothesis: In obese and lean mice that ate the same diet, tumors grew much faster in obese mice than they did in lean mice. The researchers also observed that there were far more white adipose tissue cells (called adipose stromal cells) in obese mice than in lean mice and thus turned their focus on the role of these cells.

Detailed analyses indicated cancer induced mobilization of adipose stromal cells into the circulation. Once in the tumors, some of these cells developed into fat cells, while others were incorporated into tumor-associated blood vessels.
Advertisement

Tumor-associated blood vessels support tumor growth by bringing in oxygen and nutrients vital for cancer cell survival and proliferation. Kolonin noted that the ability of adipose stromal cells to contribute to the formation of tumor-associated blood vessels is likely one of the main reasons that the excess of these cells in tumors was associated with increased malignant cell proliferation and tumor growth.

"Our data provide the first in vivo evidence of recruitment of cells from endogenous fat tissue to tumors," said Kolonin. "The fact that these cells are present in tumors is still an emerging concept. We have shown that not only are they present, but they are also functional and affect tumor growth. Identifying the signals that cause these cells to be recruited to tumors and finding ways to block them might provide a new avenue of cancer treatment."

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Bulimia Nervosa Body Mass Index Liposuction Tumor Markers For Cancer Diagnosis and Prognosis Battle of the Bulge Diabesity Hunger Fullness and Weight Control Diet and Nutrition for Healthy Weight Loss 

Most Popular on Medindia

Color Blindness Calculator Vent Forte (Theophylline) Selfie Addiction Calculator Drug - Food Interactions Loram (2 mg) (Lorazepam) A-Z Drug Brands in India Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Find a Doctor Find a Hospital

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use