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Obesity may Increase the Risk of Pediatric Multiple Sclerosis

by Iswarya on July 15, 2019 at 9:15 PM
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Obesity may Increase the Risk of Pediatric Multiple Sclerosis

Increased pediatric multiple sclerosis (MS) risk is linked to obesity, and obese patients did not respond well to first-line medications, reveals a new study. The findings of the study are published in the journal JAMA Neurology.

A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.

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In this single-center study of 453 German children with a multiple sclerosis diagnosis, obesity was connected with twofold greater odds of the disease and more frequent failure of first-line therapy with interferon beta-1a or 1b and glatiramer acetate, thereby increasing the number of patients on second-line treatment.

In this study, increased pediatric MS risk appeared to be associated with obesity, and obese patients did not respond well to first-line medicines; altered pharmacokinetics appeared to be most likely factors in treatment response, implying that gaining healthy weight or adjusting the dose according to BMI could improve therapy response.

Source: Eurekalert
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