Obesity may Increase the Risk of Pediatric Multiple Sclerosis

by Iswarya on  July 15, 2019 at 9:15 PM Research News
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Increased pediatric multiple sclerosis (MS) risk is linked to obesity, and obese patients did not respond well to first-line medications, reveals a new study. The findings of the study are published in the journal JAMA Neurology.
Obesity may Increase the Risk of Pediatric Multiple Sclerosis
Obesity may Increase the Risk of Pediatric Multiple Sclerosis

A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.

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In this single-center study of 453 German children with a multiple sclerosis diagnosis, obesity was connected with twofold greater odds of the disease and more frequent failure of first-line therapy with interferon beta-1a or 1b and glatiramer acetate, thereby increasing the number of patients on second-line treatment.

In this study, increased pediatric MS risk appeared to be associated with obesity, and obese patients did not respond well to first-line medicines; altered pharmacokinetics appeared to be most likely factors in treatment response, implying that gaining healthy weight or adjusting the dose according to BMI could improve therapy response.

Source: Eurekalert

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