Obesity may Impact Prostate Cancer Test Results in Men

Prostate cancer test results may be affected by obesity, reports a new study. The findings of the study are published in Society for Endocrinology. Using data from 970 South Australian men from the Florey Adelaide Male Ageing Study, PhD student and medical oncologist Dr Adel Aref from the University's Adelaide Medical School and the Freemasons Foundation Centre for Men's Health, studied the effects of obesity on PSA levels detected in blood and the influence of the hormones, testosterone and estrogen.

Elevated levels of prostate specific antigen (PSA) in the blood can be an indicator of prostate cancer and lead to further diagnostic investigations," says Dr Aref.

PSA is increased by the male sex steroid hormone, testosterone. "We have shown for the first time that the concentration of PSA in the blood is lower in men with severe obesity (with a body mass index or BMI of 30 or higher) than in lean men, and that this can be attributed to lower concentrations of circulating testosterone".

"The results of this study have important implications for how we should interpret PSA levels in men who are obese," says project supervisor Professor Gary Wittert, Director of the Freemasons Foundation Centre for Men's Health and the Adelaide Medical School at the University of Adelaide and SAHMRI.

"Obesity is a major risk factor in the development of cancer, as well as other diseases. More than 65% of men in Australia are overweight or obese and this level is predicted to increase.

"Further studies are now required to investigate effective strategies for applying this knowledge in clinical practice" says Professor Wittert.

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Source-Eurekalert