A new study has suggested that the increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability (MSI), a common condition in most colorectal cancers.
Peter T. Campbell, of the Epidemiology Research Program at the American Cancer Society in Atlanta, and colleagues performed a case-control study of subjects with incident colorectal cancer and their unaffected sex-matched siblings to evaluate associations between being overweight or obese (defined according to body mass index) and adult weight change and colorectal cancer risk.
Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.
Patients that are diagnosed with tumors that are microsatellite-stable or MSI-low have lower 5-year survival rates than patients with tumors that are MSI-high.
Recent body mass index (people over 30 kg/m2 or more, the cut off for obesity) was positively associated with overall risk of colorectal cancer for men and women combined.
Colo-rectal Cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
"Our data also suggest that the associations between [body mass index] and adult weight gain and the risk of colorectal cancer differ between MS-stable and MSI-high tumors... suggesting differing underlying etiologies for colorectal cancer according to tumor MSI," the authors said.
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Obesity - Causes, Symptoms, Diagnosis, Complications, Treatment
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.
Source-ANI
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Ideal Body Weight - A Global Issue
India and China, which are epicenters of a booming economy, are now witnessing a steady rise in obesity. Globalization is the prime accused.
India and China, which are epicenters of a booming economy, are now witnessing a steady rise in obesity. Globalization is the prime accused.
