Nuclear-based breast imaging tests could increase the risk of radiation-induced cancer, reports a new study.
However, the radiation dose and risk from mammography are very low.
"A single breast-specific gamma imaging (BSGI) or positron emission mammography (PEM) examination carries a lifetime risk of inducing fatal cancer greater than or comparable to a lifetime of annual screening mammography starting at age 40," said the study's author, R. Edward Hendrick, clinical professor of radiology at the University of Colorado-Denver, School of Medicine in Aurora, Co.
Preliminary studies have shown both to be promising at detecting cancer; however, both involve the injection of radioactive material into the patient.
BSGI uses a high-resolution gamma camera that allows for imaging with mild compression of the breast along with an injection of a nuclear radiotracer, which is absorbed at a higher rate by cancerous cells.
In PEM, radioactive material is injected into the body to measure metabolic activity and determine the presence of disease. Other technologies, not yet approved by the FDA, include dedicated breast CT and digital breast tomosynthesis.
Dr. Hendrick reviewed recent studies on radiation doses from radiologic procedures and organ doses from nuclear medicine procedures, along with Biologic Effects of Ionizing Radiation (BEIR) VII age-dependent risk data, to estimate the lifetime risk of radiation-induced cancer incidence and death from breast imaging exams using ionizing radiation.
Two-view digital mammography and screen-film mammography were found to have an average lifetime risk of fatal breast cancer of 1.3 and 1.7 cases, respectively, per 100,000 women aged 40 years at exposure and less than one case per one million women aged 80 years at exposure. Annual screening mammography (digital or screen-film) performed in women from age 40 to age 80 is associated with a lifetime risk of fatal breast cancer of 20 to 25 cases in 100,000.
"Dedicated breast CT and digital tomosynthesis were both found to have an average lifetime risk of fatal breast cancer of 1.3 to 2.6 cases, respectively, per 100,000 women 40 years of age at exposure.
A single BSGI exam was estimated to involve a lifetime risk of fatal cancer 20 to 30 times that of digital mammography in women aged 40 years, while the lifetime risk of a single PEM was 23 times greater than that of digital mammography. In addition, while mammography only slightly increases a woman's risk for breast cancer, BSGI and PEM may increase the risk of cancers in other organs as well, including the intestines, kidneys, bladder, gallbladder, uterus, ovaries and colon.
The reports have appeared online and in the October issue of Radiology.