A novel thermo-sensitive injectable hydrogel that has been engineered with gene-modified bone marrow mesenchymal stromal cells (BMSCs) can be effective in repairing articular cartilage defects, a new study by researchers at Micro Orthopaedics, Zhongnan Hospital of Wuhan University reveals.
The chitosan and polyvinyl alcohol composite hydrogel containing hTGFβ-1 gene modified BMSCs was injected into rabbits with defective articular cartilage. Sixteen weeks later the defected cartilage regenerated and was proven to be hyaline cartilage. This work can be found in the January 2013 issue of Experimental Biology and Medicine.
Osteochondritis Dissecans
Osteochondritis dissecans is a relatively rare condition. It is an important cause of joint pain in physically active adolescents.
Advertisement
"No reliable approach is currently available for complete restoration of damaged articular cartilage", said Dr. Bai-wen Qi, "in this study, CS/PVA gel was combined with rabbit bone marrow stromal cells (BMSCs) transfected with hTGFβ-1 and used to repair rabbit articular cartilage defects and the repair effect was evaluated".
Tissue engineering combined with gene therapy technology has the potential to manage the repair of defective articular cartilage. In this study, through minimally invasive injection methods the authors were able to repair rabbit articular cartilage defects with CS/PVA gel and gene modified BMSCs. Dr. Qi said "CS/PVA gel can be applied to the repair of articular cartilage defects as an injectable material in tissue engineering, and the regenerated cartilage can secrete cartilage matrix and perform the functions of hyaline cartilage. Use of this gel for cartilage repair has advantages such as the minor surgical procedure required, tight bonding with the damaged tissue and lack of rejection".
![Fracture of Knee Cap]( "Fracture of Knee Cap")
Patella fracture is a kneecap injury that needs surgical correction. Undisplaced fracture can be healed by using a brace to keep the knee immobile.
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "The study by Qi and colleagues is very exciting as it combines tissue engineering and gene therapy approaches to successfully repair defective articular cartilage. The approach should be adaptable in the future to human tissue repair".
Source: Eurekalert
Fracture of Knee Cap
Patella fracture is a kneecap injury that needs surgical correction. Undisplaced fracture can be healed by using a brace to keep the knee immobile.
Advertisement
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "The study by Qi and colleagues is very exciting as it combines tissue engineering and gene therapy approaches to successfully repair defective articular cartilage. The approach should be adaptable in the future to human tissue repair".
Source: Eurekalert
Knee Replacement
Make sprinting a possibility! Relieve chronic arthritic pain by having a knee replacement done at affordable prices. Check out our list of world-class hospitals.
Advertisement
Advertisement
|
Advertisement
Latest Research News
Tobacco smoke contains toxic chemicals which damage lungs, weaken the immune system and cause tuberculosis.
Identifying an unappreciated relationship between brain shape and activity overturns the century-old paradigm emphasizing the importance of complex brain connectivity.
Decoding the eight factors affecting Black adults' life expectancy.
Sobering truth about foot travel in the United States emerges from international statistics, highlighting the prevalence of walking on the Blacksburg campus.
Unveiling a hidden mechanism, proteins within brain cells exhibit newfound abilities at synapses, reinforcing Darwin's theory of adaptation and diversity in the natural world.