University of California, San Diego scientists have developed a novel technique that would pave way for more effective treatments for liver disease. During the study, researchers utilized an array system that can identify the biological components that can lead to or alleviate liver disease. It works by controlling the range of environments surrounding star-shaped liver cells called hepatic stellate cells (HSCs), cells involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. Current approaches to identify the factors affecting HSC biology typically focus on each factor individually, ignoring the complex cross-talk between the many components acting on the cells. The high-throughput cellular array technology developed by UCSD researchers systematically assesses and probes the complex relationships between hepatic stellate cells and components of their microenvironment. By doing this, they found that certain proteins are critical in regulating HSC activation and that the proteins influence one another's actions on the cells. The new technique was developed by Shu Chien, co-author of the paper and bioengineering professor and director of the Institute of Engineering Medicine at UCSD. "In one step we can look at the physical and chemical micro-environment of the cells," Chien added. "Now we can look at the optimum condition that is best for the cells to proliferate and differentiate." "By looking at the array you get hundreds of different combinations of proteins and you can look at hundreds of cells at once," said Dr David Brenner, Vice Chancellor for Health Sciences and Dean of the UCSD School of Medicine. "This will give us new insights for the treatment for liver fibrosis, and it will give us the platform to test new treatments," he added. The study appears in journal Integrative Biology. Source: ANIARU << Two-Year-Old Boy In Britain Shows Amazing Intelligence China to Stop Mandatory Hepatitis B Tests >> Recommended Reading Pathbreaking Study Develops Liver Cells From Skin Cells In a breakthrough study, researchers at The Medical College of Wisconsin in Milwaukee have succeeded in producing liver cells from patients' skin cells. READ MORE Human Cells Converted to Liver Cancer by Parasite Growth Hormone The human liver fluke ( Opisthorchis viverrini ) contributes to the development of bile duct (liver) cancer by secreting granulin READ MORE Medication in Early Stages of Disease Effective for Acute Liver Failure Study says the antidote for acute liver failure caused by acetaminophen poisoning also can treat acute liver failure due to most other causes if given before severe injury READ MORE Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Biliary Cirrhosis Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Sinopril (2mg) (Lacidipine) Hearing Loss Calculator Color Blindness Calculator More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseBiliary CirrhosisMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?