Novel Peptide from Spirulina Extract may Help Fight Hypertension

by Iswarya on Dec 31 2018 3:36 PM

Novel Peptide from Spirulina Extract may Help Fight Hypertension
New study finds that a novel peptide isolated from the spirulina extract is capable of dilating arteries, thus leading to antihypertensive action. The findings of the study are published in the journal Hypertension.
Spirulina is more and more celebrated as a "superfood" because of its possible beneficial properties, albeit its mechanism of action is still subjected to investigation. With the scientific name of Arthrospira platensis, spirulina is a cyanobacterium, a bacterium capable of photosynthesis. Sometimes classified as a "blue algae," it was supposedly used as a food by the Aztecs.

Now research from the Vascular Physiopathology Laboratory of the I.R.C.C.S. Neuromed in Pozzilli (Italy) shows that one of its extracts may counteract arterial hypertension by dilating blood vessels. "Our research - says Albino Carrizzo, first author of the paper - started by conducting simulated gastrointestinal digestion on the raw extract of spirulina. In other words, we reproduced what happens in the human gut after ingesting the substance. This way we have been able to isolate the peptides that would be absorbed by our body ".

One of the isolated peptides, named SP6, has been identified for the first time. Administered to isolated blood vessels in the lab, it showed vasodilatory action, a potentially antihypertensive effect. This led researchers to administer SP6 to hypertensive animals, resulting in an effective lowering of blood pressure.

"We know - says Carmine Vecchione, Professor at the University of Salerno and head of Vascular Physiopathology Laboratory at Neuromed Institute - that hypertensive patients often have a defect in the natural processes that, by the action of nitric oxide, regulate endothelium (the inner wall of blood vessels). The peptide we isolated in spirulina extract acts positively on this mechanism. Of course, further researches will be necessary, but we think that SP6 could be a natural adjuvant to common pharmacological therapies in order to improve endothelial function and, consequently, combat hypertension".