Novel Pain-Sensing Brain Network Linked to Chronic Pain in Parkinson's Disease: Study

by Iswarya on  August 29, 2018 at 4:33 PM Mental Health News
RSS Email Print This Page Comment bookmark
Font : A-A+

New brain network is associated with pain in Parkinson's disease (PD) to a particular region of the brain, reports a new mice study. The findings of the study are published in the journal eLife.
Novel Pain-Sensing Brain Network Linked to Chronic Pain in Parkinson's Disease: Study
Novel Pain-Sensing Brain Network Linked to Chronic Pain in Parkinson's Disease: Study

The research reveals why a subset of neurons in part of the brain called the subthalamic nucleus is a potential target for pain relief in PD, as well as other diseases such as dementia, motor neuron disease and Huntington's, and certain forms of migraine.

People with PD often report unexplained pain such as burning, stabbing, aching, itching or tingling sensations that are not directly related to their other PD symptoms.

Treatment with deep brain stimulation in the subthalamic nucleus can help with the movement-related symptoms of PD, but recent studies have shown it also reduces pain. The way it does this, however, is currently unclear.

"In this study, we set out to determine whether the subthalamic nucleus is involved in translating a harmful stimulus such as injury into pain, and whether this information transmission is altered in PD," explains lead author Arnaud Pautrat, PhD Student at Grenoble Institut des Neurosciences (Inserm, National Institute for Health and Medical Research/University Grenoble Alpes), France.

The team started by using electrophysiology to measure the firing of electrical signals in nerve cells in the subthalamic nucleus of rats given a shock to their back paw. Nerve cells were indeed temporally activated by this stimulation. They also found that the neurons fell into three response groups, showing an increase, decrease or no change in their baseline firing rate.

They next looked at whether these responses caused a change in brain function. Rats with a damaged subthalamic nucleus took much longer to show signs of discomfort than healthy rats. When they expanded their study to rat models of PD, the team found that nerve cells in the subthalamic nucleus had higher firing rates and the responses to pain were bigger and longer than in the healthy animals. Taken together, this suggests that dysfunctional pain-processing pathways in the subthalamic nucleus are the cause of PD-related pain.

To understand where the pain signals to the subthalamic nucleus were coming from, the team looked at two brain structures known to be important in relaying damage signals from the spinal cord: the superior colliculus and the parabrachial nucleus. Blocking their activity revealed that both structures play a crucial role in transmitting pain information to the subthalamic nucleus, and that a direct communication pathway exists between the parabrachial nucleus and the subthalamic nucleus.

As a result, the team believes this pathway is likely to be involved in the beneficial effects of deep brain stimulation on pain in PD and that these novel insights could help to target stimulation to specific parts of the brain to make it more effective as a pain reliever.

"We have found evidence that the subthalamic nucleus is functionally linked to a pain-processing network and that these responses are affected in Parkinsonism," concludes senior author and Inserm researcher Veronique Coizet, PhD.

"Further experiments are now needed to fully characterise the effects deep brain stimulation on this brain region in our experimental models, with a view to finding ways to optimise it as a treatment for pain caused by Parkinson's and other neurological diseases."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Thoracic Outlet Syndrome Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) How to Cope with Cancer Pain Complex Regional Pain Syndrome (CRPS) 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive