About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Novel Mechanism To Increase The Effectiveness Of New Target-Based Cancer Therapies Developed

by Aruna on September 7, 2009 at 9:59 AM
Font : A-A+

Novel Mechanism To Increase The Effectiveness Of New Target-Based Cancer Therapies Developed

Researchers in Canada have come across a novel mechanism that may be instrumental in the development of new, more effective cancer therapies.

They have discovered that activation mechanism of the RAF protein kinase which, when mutated, is responsible for more than 25 per cent of cancers.

Advertisement

Understanding this mechanism may lead to novel anti-cancer agents designed to minimize the toxic side effects caused by chemotherapy.

The RAF family of kinases is key in regulating various cellular processes including cell growth, differentiation and survival.

Marc Therrien at the Institute for Research in Immunology and Cancer (IRIC) of the Universiti de Montrial, and Frank Sicheri, at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital in Toronto claim that dimerization, or combination, of two RAF proteins is essential to its activation.
Advertisement

Inhibiting the dimerization of RAF may therefore block its activation, thus stopping cancer cells from growing.

The study exposes not only the activation mechanism of RAF, but potentially the mechanisms that control other protein kinases, a large number of which are linked to cancer and other diseases such as diabetes, hypertension and neurodegeneration.

"Basic researchers believe that one of the most promising strategies to finding lifelong cures for cancers lies in understanding the molecular underpinnings specific to cancer cells," Nature quoted Therrien as saying.

"It is hoped that this will translate to the development of inhibitors tailored to specific molecular defects and, as a result, should increase the effectiveness of new target-based cancer therapies," he added.

Sicheri said, "protein kinases are the targets for some of the most successful anti-cancer drugs in the clinic."

"Now that we have discovered how to turn off the RAF protein without interfering with other proteins, we may be able to design drugs that have unprecedented precision in targeting cancer cells while reducing the toxic side effects for patients," he added.

Source: ANI
ARU
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Link between Dietary Intake of Plant-based Essential Fatty Acids and Death Risk
Aspirin may be Harmful When Used for Preventing 1st Heart Attack, Stroke
Pregnancy Complications Elevated Among Symptomatic COVID-19 Women
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Anti-Cancer Therapy May Depend On The 'Hedgehog' Pathway
Scientists in Switzerland have discovered a way to block the growth of human colon cancer cells, ......
New Light-Sensitive Compounds May Revolutionize Cancer Therapy
American chemists have developed new compounds that show promise for photodynamic cancer therapy, .....
Cancer Therapy Success may be Determined by Oxygen and MRI
A simple magnetic resonance imaging (MRI) test involving breathing oxygen might help oncologists ......
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use