Does The Pathological Role Of Tau-Protein Differ In Non- Alzheimer's Dementia?
Reduction in tau protein may not protect against Parkinson's and Lewy body dementias.
Reduction in tau protein may not protect against Parkinson's and Lewy body dementias.
‘Study offers novel findings on how mutant tau proteins impact the function of mitochondria (the powerhouse of the cell) in human neurons, thereby playing a role in neurodegenerative diseases.
’
Tweet it Now
Moreover, the study also finds a mechanism for how tau gets released from neurons and spreads throughout the brain, a pathological process that is strongly correlated with disease progression. “Understanding the mechanisms of what is happening within cells during disease is key to discovering new ways to treat neurodegenerative diseases including Alzheimer’s, which is the most common tauopathy. We hope that other researchers take advantage of our ‘tau interactome’ which is a broad and unbiased survey of tau interacting proteins in the cell that could be contributing to disease.” “Showing a potential mechanism for how tau gets released can inform future studies into how we can prevent diseased tau from getting out of neurons and spreading throughout the brain,” says Buck Institute assistant professor Tara Tracy, PhD, lead author of the paper.
Source-Medindia
Tau Protein Can Aggregate Even In Normal Body Conditions
New method with high-resolution microscopy and machine learning identifies tau aggregates that occur in healthy body structures.
New method with high-resolution microscopy and machine learning identifies tau aggregates that occur in healthy body structures.
Formation Site of Tau Protein Tangles in Alzheimer�s Disease Revealed
Automated imaging method – PET imaging can track the formation of pathological TAU protein clumps seen in the brain of Alzheimer's disease.
Automated imaging method – PET imaging can track the formation of pathological TAU protein clumps seen in the brain of Alzheimer's disease.
