About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Novel Genetic Factors Linked to Kidney Stones Development: Study

by Iswarya on April 12, 2019 at 12:21 PM
Font : A-A+

New genetic factors discovered are more likely to contribute to the development of kidney stones, reports a novel study. The findings of the study are published in the Journal of the American Society of Nephrology.

The findings of the study may be useful for predicting individuals' risk of developing kidney stones and for identifying new targets for prevention and treatment.

Highlights

  • A large genome-wide association study has identified 14 variants including nine new variants at different locations in the genome that are linked to the development of kidney stones.
  • Four of the variants were related to obesity, high triglycerides, or high blood uric acid levels. The remaining ten variants were associated with kidney- or electrolyte-related traits that might affect crystallization pathways that lead to kidney stone formation.

Novel Genetic Factors Linked to Kidney Stones Development: Study

Increasing numbers of adults are developing kidney stones, a condition called urolithiasis, and they often experience considerable pain and frequent recurrences. To date, six genetic variants have been linked to urolithiasis, and the role of these variants are not well understood.

To provide new insights into the condition and its potential genetic causes, a team led by Koichi Matsuda, MD, PhD and Chizu Tanikawa, PhD (The University of Tokyo) performed a large-scale analysis of the entire genomes of 11,130 Japanese patients with urolithiasis and 187,639 controls, followed by a replication analysis of 2,289 affected patients and 3,817 controls.

Advertisement


The analysis revealed 14 variants at different locations in the genome that were linked to urolithiasis, including nine new variants. Four of the variants were related to obesity, high triglycerides, or high blood uric acid levels. The remaining ten variants were associated with kidney- or electrolyte-related traits that might affect crystallization pathways that lead to kidney stone formation.

"To the best of our knowledge, this study included the largest number of urolithiasis cases," Dr. Matsuda. "Because urolithiasis is a preventable disease by changing lifestyle factors such as hydration, weight control, and food intake the study's results are useful for risk prediction and disease prevention," said Dr. Matsuda.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Kidney Stones Kidney Stones in Children Ureteroscopy for Stone Urinary Stone Disease Genetics and Stem Cells Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Diet for Kidney stones Kidney Disease 

Most Popular on Medindia

Color Blindness Calculator Post-Nasal Drip Drug Side Effects Calculator Vent Forte (Theophylline) Blood Donation - Recipients Pregnancy Confirmation Calculator Find a Hospital Nutam (400mg) (Piracetam) Loram (2 mg) (Lorazepam) Calculate Ideal Weight for Infants

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE