Novel Factor Involved in Autophagy Identified

by Julia Samuel on February 13, 2015 at 4:31 PM

Protein deposits in the brain is a major characteristic of neurodegenerative disorders such as Alzheimer's disease. These proteins are defective, insoluble, no longer fulfil their function and which cells are unable to break down.

Professor Christian Behl of the Institute of Pathobiochemistry, University Medical Center of Johannes Gutenberg University, Mainz has determined the RAB3GAP complex as a novel factor that influences the efficient degradation of proteins.

Amnesia

Amnesia, is profound memory loss caused by a physical injury inflicted on the brain, by an infection or by a traumatic or emotional experience.

The researchers were able to show that the complex plays an important role in autophagy, a physiological process that breaks down cellular proteins and organelles. This insight opens up possible new options for the development of therapeutic and preventive approaches for neurodegenerative diseases.

Autophagy could be excessive or damaged organelles, such as mitochondria, invading pathogens, such as viruses or bacteria, or cytoplasmic macromolecules.

Alzheimers Disease

Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.

Autophagy serves on the one hand for the recycling of the building blocks of cells and the provision of energy, but is also activated specifically in stress situations.

The research group discovered that the RAB3GAP complex promotes the formation of autophagic vesicles. These are bubble-like structures with a lipid shell that envelop the substrates to be degraded.

The autophagic vesicles then fuse with lysosomes, simple cell organelles, which contain digestive enzymes that break down the substrates into their component parts.

Professor Christian Behl said, "The controlled protein degradation by autophagy is a core aspect of protein homoeostasis, which means the complex interplay between the formation, folding, and decomposition of proteins. We have extended our understanding of age-related disorders by identifying new factors involved in this process."

Source: Medindia

Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob disease (CJD) is a rare form of degenerative brain disorder, or brain damage that leads to a rapid decrease of mental function and movement.

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