Novel Drug may Improve Memory in People With Moderate Alzheimer's Disease

by Sheela Philomena on March 13, 2013 at 11:35 AM

In people with moderate Alzheimer's disease, a new drug was found to improve memory problems, finds study. The drug is called ORM-12741.

The drug is the first to target a specific subtype of adrenergic receptors (alpha-2C) in the brain, which are believed to be involved in modulation of brain functions under stressful conditions, or the "fight or flight" response. For the clinical trial, 100 people with moderate Alzheimer's disease were randomly given either 30 to 60 milligrams or 100 to 200 milligrams of ORM-12741 or matching placebo pill twice a day for three months as add-on therapy to a cholinesterase drug. Additionally, use of memantine was allowed. These are the other Alzheimer drugs currently on the market. Neither the researchers nor the participants knew which treatments participants were receiving.

Alzheimers Disease

Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.

After three months, researchers retested several aspects of the participants' memory and behavior. Those who took ORM-12741 tested higher on the tests of memory compared to those who received the placebo pill. At three months, the memory scores for those who received the placebo pill had worsened by 33 percent, whereas the scores improved by 4 percent for those who took ORM-12741.

"Currently, there are still only a handful of Alzheimer's drugs on the market and they have only moderate effects on the symptoms of the disease," said study author Juha Rouru, MD, of Orion Pharma in Turku, Finland. "Anytime you have a drug that targets a new pathway in the brain and shows effectiveness in clinical trials, it is exciting."

It is estimated that 13.8 million people will have Alzheimer's disease by 2050.

Source: Eurekalert

Quiz On Alzheimer’s Disease

Alzheimer's disease (AD) is the most common form of dementia. Participate in this quiz to find out how much you know about this debilitating disease.

<< Some Bacteria may Protect Against Diseases: Study

Job Burnout Ups Risk of Heart Disease >>

Caring for Alzheimers disease patients

Alzheimer's disease is a complex brain disorder that triggers the most common form of dementia. The slide show will show how patients need support and care as dementia progresses.