
A new diagnostic tool for bladder cancer has been developed by researchers from the Danish Cancer Society and the Herlev University Hospital of Copenhagen.
The related report by Serizawa et al, "Custom-designed MLPA using multiple short synthetic probes: application to methylation analysis of five promoter CpG islands in tumor and urine specimens from patients with bladder cancer," appears in the July 2010 issue of The Journal of Molecular Diagnostics.
Bladder cancer is the fourth most common type of cancer in men in the United States. Over 50,000 men are diagnosed with bladder cancer each year. Although early-stage superficial tumors can be shaved off or treated with BCG immunotherapy, late-stage patients with infiltrating tumor often require a cystectomy (removal of all or part of the bladder). Therefore, early diagnosis of bladder cancer is critical in maintaining lifestyle standards.
Serizawa et al suggest that "the use of multiple short synthetic probes may provide a simple and cost-effective approach to custom-designed MLPA." In future studies, Dr. Guldberg's group will examine how "the same approach may be used for most other MLPA applications and thus provide the basis for a more widespread usage of the MLPA technology."
Source: Eurekalert
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