Novel Consortium of Bacteria for Digestive Disorders

Inflammatory bowel disease (IBD), is a debilitating group of chronic diseases including Crohn’s Disease (CD) and ulcerative colitis (UC), which causes inflammation of the gut with altered gut microbiota are treated with steroids, immunosuppressants, liquid diet or surgery to reduce the symptoms.

A new study published in Nature Communications demonstrates a consortium of bacteria is designed to complement missing or underrepresented functions in the imbalanced microbiome of inflammatory bowel disease (IBD) patients to prevented and treat the chronic immune-mediated colitis in humanized mouse models.

Inflammatory Bowel Disease - Causes, Symptoms, Diagnosis, Treatment & Prevention
Inflammatory bowel disease involves chronic inflammation of the colon and small intestine. Symptoms include diarrhea, abdominal pain and weight loss.

‘Novel treatment of inflammatory bowel disease increases the good bacteria and decreases the bad bacteria.’

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"The idea with this treatment is to restore the normal function of the protective bacteria in the gut, targeting the source of IBD, instead of treating its symptoms with traditional immunosuppressants that can cause side effects like infections or tumours," said Sartor, MD, Midget Distinguished Professor of Medicine, Microbiology and Immunology, Co-Director of the UNC Multidisciplinary IBD Centre.

Live bacteria consortia, called GUT-103 and GUT-108, were developed by biotech firm Gusto Global were given orally three times a week to a humanized mouse model with no bacteria permits the bacteria to stay in the colon for an extended amount of time.

These therapeutic bacteria consortia reverse established inflammation and decrease bacteria that can cause harm while increasing resident protective bacteria to promote mucosal healing and immunoregulatory responses.

Genetic Test to Predict Inflammatory Bowel Disease Risk in Children
New genetic test helps in early diagnosis of inflammatory bowel disease in children and also predict its severity.

The results of this study show the need for more alternative therapies to treat inflammatory bowel disease and more clinical trials in the future.

Food Dyes can Cause Colitis
Food colorants such as Red 40 and Yellow 6 are widely used in food, drink, and medicine around the world. Consuming such foods can cause colitis, a form of inflammatory bowel disease (IBD).

Source-Medindia

Foul Smelling Stool
Foul smelling stool is a stool that has a bad odor. Poor diet and indigestion are the most common causes of smelly stool although, it can also occur due to various underlying disease conditions.