About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Novel Classification Helps Diagnose and Treat Cancer Better

by Hannah Joy on February 13, 2018 at 12:17 PM
Font : A-A+

Novel Classification Helps Diagnose and Treat Cancer Better

A novel approach helps classify 10,000 human cancers of 32 different types into ten classes based on their molecular pathways and aids in the development of new ways to diagnose and treat cancer.

"When we study cancer at the molecular level we realize that there is not a single pathway or process that drives all the different types of cancer," said first author Dr. Chad Creighton, associate professor of medicine and member of the Dan L Duncan Comprehensive Cancer Center division of biostatistics at Baylor College of Medicine.

Advertisement


The study appears in the journal of Clinical Cancer Research.

Past studies have looked at cancers of individual types in detail. Lung cancer studies, for example, have defined molecular-based lung cancer subtypes that represent different molecular pathways that have been perturbed and driven lung cancer growth.
Advertisement

"In this study, we wanted to find common pathways across cancers from different tissues," Creighton said. "We used the Cancer Genome Atlas, a publicly available data set that allows us to look at what many types of cancers have in common."

The researchers applied a different computational approach to subtract all tissue-specific differences and identify what pathways remained. They analyzed about 10,000 human cancers of 32 different types and were able to define ten major cancer groups that they call classes.

Most classes include cancers from different tissues that have in common specific molecular pathways that are altered and potentially driving cancer growth. Then, the researchers identified particular genes that characterize each of those classes to understand better what the pathways do.

Altered pathways

"We found a class that had a very high expression of altered genes that are involved in the immune checkpoint, which refers to tumor molecules that signal the immune cells in charge of destroying the tumor to leave it alone," Creighton said. "Other classes had altered genes in pathways linked to metabolism or stress."

Another subset had a molecular signature of neuroendocrine tumors, a type of tumors that can be found within a wide range of tissues, but it has its unique characteristics and profile.

"We expected that about 1 percent of the tumors would show a neuroendocrine signature, but we found that about 4 percent were showing this," Creighton said. "This represents a substantial number of patients when you consider all human cancers."

Even though the tumors were not diagnosed initially as neuroendocrine tumors, they had a signature of this type of cancer. For the researchers, this finding suggests that there might be some neuroendocrine cancers that are being missed.

"We think there is a need for reconsidering what type of markers to look for to identify neuroendocrine tumors," Creighton said.

Some of the biological pathways identified in this study have been explored in the laboratory setting, for years now.

"Many human cancers manifest these pathways that we found to be relevant in the laboratory setting," Creighton said. "We think it is very important to map out the pathways cancer seems to be used to grow. Knowing this can be the first step in determining how to target that particular cancer better."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of ....
Pre-Cancerous Lesions
Encyclopedia section of medindia gives general information about Pre Cancerous Lesions...
AIDS-HIV-Cancer
AIDS defining malignancies are cancers that occur in patients with AIDS due to their low immunity....
Ampullary Cancer
Ampullary cancer is a rare cancer of the ampulla of Vater that connects the common bile duct and ......
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use