About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Nonhuman Primates Protected Against Lethal Ebola Sudan Infection

by Bidita Debnath on August 22, 2016 at 10:33 PM
Font : A-A+

 Nonhuman Primates Protected Against Lethal Ebola Sudan Infection

Experts at The University of Texas Medical Branch at Galveston, in collaboration with Arbutus Biopharma Corporation, have protected nonhuman primates against Ebola Sudan four days following exposure to the virus.

The study results, which were recently published in Nature Microbiology, demonstrated that the treatment was effective at a point when animals have detectable levels of the virus in their system and were at an advanced stage of disease.

Advertisement


"This is a key step in our efforts to protect people from this terrible, lethal disease," said Thomas Geisbert, UTMB professor of microbiology and immunology. "The Ebola virus has five different species and will continue to impact people throughout the African continent, unfortunately with a high mortality rate."

Geisbert noted that significant progress has been made in developing therapeutics against Ebola Zaire, the species responsible for the 2014-15 outbreak in West Africa. However those drugs may not be effective against Ebola Sudan. "That's why this latest study could be instrumental in reducing Ebola outbreaks," Geisbert said.
Advertisement

Since 2010, Ebola Sudan has been responsible for three outbreaks and until 2014, caused the largest outbreak of Ebola hemorrhagic fever on record, with 425 confirmed cases in Uganda in 2000.

"We were able to protect all of our nonhuman primates against a lethal Ebola Sudan infection when treatment began four days following infection," Geisbert said. "At this point, those infected showed signs of disease and had detectable levels of the virus in their blood."

Although all infected animals showed evidence of serious disease, those receiving the treatment survived and recovered. The untreated controls succumbed to the disease 8-10 days after exposure and had a disease course similar to that reported for Ebola Sudan-infected patients during outbreaks.

The treatment uses a specific short strand of RNA, known as siRNA, designed to target and interfere with the Ebola Sudan virus, rendering it harmless. One of the advantages of this approach is the ability to modify it to different viral species or strains. The siRNAs are delicate, so the researchers encapsulated them using a proprietary lipid nanoparticle (LNP) delivery technology platform developed by Arbutus Biopharma to protect the siRNAs in the bloodstream and allow efficient delivery and cellular uptake by the target cells. This clinically validated technology has been used successfully to protect non-human primates against Ebola Zaire and Marburg virus infection.

"Demonstrating protection in this uniformly lethal model of Ebola Sudan sets a high bar for determining effectiveness, as subjects were infected with a high viral dose that mimics the worst-case scenario of a needle-stick injury with concentrated viral material," said Geisbert. "The survival benefit and rapid control of viral replication with this treatment illustrate the strong potential of this evolving technology platform in combatting lethal viral infections."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
Test  Your Knowledge on Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Flu Congo Fever Ebola Virus Disease 

Most Popular on Medindia

Pregnancy Confirmation Calculator Vent Forte (Theophylline) Post-Nasal Drip Drug - Food Interactions Find a Doctor The Essence of Yoga Turmeric Powder - Health Benefits, Uses & Side Effects A-Z Drug Brands in India Noscaphene (Noscapine) Daily Calorie Requirements
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Nonhuman Primates Protected Against Lethal Ebola Sudan Infection Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests