To prevent nonalcoholic fatty liver disease - the most common cause of chronic liver disease worldwide - in mice, researchers have discovered a way. According to investigators at Washington University School of Medicine in St. Louis, blocking a path that delivers dietary fructose to the liver prevented mice from developing the condition. First author Brian J. DeBosch, MD, PhD, clinical fellow in pediatric gastroenterology, said that there are competing hypotheses about the origins of metabolic syndrome and one of these hypotheses is that insulin resistance begins to develop in the liver first. The research team, led by Kelle H. Moley, MD, the James P. Crane Professor of Obstetrics and Gynecology, showed that a molecule called GLUT8 carries large amounts of fructose into liver cells. In this study, researchers showed that blocking or eliminating GLUT8 in mice reduced the amount of fructose entering the organ and appeared to prevent the development of fatty livers. Mice with GLUT8 deficiency also appeared to burn liver fat at a faster rate than control mice. The researchers also saw differences between male and female mice in the degree to which they were protected from fatty livers and in whole-body metabolism. Male mice fed a high-fructose diet while deficient in GLUT8 still had evidence of fatty liver disease, but whole-body metabolism was healthy. They showed no evidence of metabolic syndrome in the rest of the body. Females fed fructose while lacking GLUT8, in contrast, had healthy looking livers but exhibited more evidence of whole-body metabolic syndrome. The study has been published in The Journal of Biological Chemistry.Source: ANI << Super Giant Uterine Fibroid Removed – Yet Another Milestone ... Are E-Ciggies So Cool? >> Recommended Reading Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Deadly Complications of Liver Disease can be Prevented by Probiotics New research suggests that probiotics are effective in preventing hepatic encephalopathy in patients with cirrhosis of the liver. READ MORE Higher Mortality Rate in Lean Patients With Fatty Liver Disease Lean patients with nonalcoholic fatty liver disease have higher overall mortality rate than obese persons, despite being of a healthier weight, reports a new research. READ MORE Steroids Ineffective and Possibly Harmful in Pediatric Liver Disease Treating infants with high doses of steroids fails to improve medical outcomes in the end-stage pediatric liver disease biliary atresia, says a new study. READ MORE Biliary Cirrhosis Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Drug Interaction Checker Drug - Food Interactions Selfie Addiction Calculator More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseBiliary CirrhosisMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?