This region has the lowest coverage of potable water in the world, housing 18 percent of the world's population with no access to drinking water.
"Five years to the 2015 deadline for the achievement of the Millennium Development Goals (MDG), the water and sanitation situation in West and Central Africa remains a major concern," UNICEF said in a statement.
According to the organization only eight of 24 countries in the region are on track to meet water target goals -- Benin, Burkina Faso, Cameroon, Cap Verde, Gabon, Ghana, Guinea et Mali).
"The total number of people in the region without access to improved drinking-water sources actually increased over the 1990-2008 period from 126 million people to 155 million."
This means that despite an improvement in coverage from 49 percent in 1990 to 61 percent in 2008 -- countries needed to reach 75 percent by 2015.
"More than 155 million people (39 percent) were without access to improved drinking-water sources in 2008 and the small pace of increase failed to keep pace with the expanding population in the region," read the statement.
Six countries have less than 50 percent drinking water coverage: Chad, Democratic Republic of the Congo, Equatorial Guinea, Niger, Mauritania and Sierra Leone.
Also of concern is the fact that 291 million people in West and Central Africa have access to no sanitation at all - in the region with the highest under-five mortality rate of all developing regions at 169 child deaths per 1,000 live births.