Nine genes that can make a person gain weight in a pre-existing condition of high body mass index have been identified by recent research at McMaster University

‘In addition to lifestyle factors, genetic factors also play an important role in obesity, with 50 to 80 percent of body mass index related to genetics.’

"The effect of these genes may be amplified by four times, if we compare the 10% of the population at the low end of the body mass index, compared to the 10% at the high end," he added.




Although the increasing average body mass index of the population of several high-income countries has recently plateaued, the researchers note in the study, the cases of extreme forms of obesity are still growing. People who are morbidly obese are at risk of health complications such as diabetes, cardiovascular disease, hypertension and cancers and early death.
On top of lifestyle factors such as unhealthy diet and physical inactivity, genetic factors are also known to play an important role, with 50 to 80 per cent of body mass index related to genetics.
The researchers, in a study published today in the American Journal of Human Genetics, looked at 37 genes that are well established as modulating the body mass in 75,230 adults with European ancestry and found the nine with the snowball effect.
"These genes may, in part, explain why some individuals experience uncontrolled and constant weight gain across their life, despite the availability of different therapeutic approaches," said Meyre. "The plausible explanation is that there are interactions between the snowball obesity genes and risk environmental factors."
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"We have an important message of hope that the carriers of these genes, if they stay in the low end of body mass index through appropriate lifestyle, may minimize the effect of the snowball obesity genes."
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