Nicotine and Caffeine Withdrawal may Lead to Unnecessary Suffering and Testing in Intensive Care Patients: Study

by Colleen Fleiss on  June 2, 2019 at 11:22 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

In intensive care units (ICUs), nicotine and caffeine withdrawal cause unnecessary suffering to patients and also lead to unwanted laboratory testing and diagnostic imaging such as X-rays and MRIs, stated a systematic review of clinical and observational studies involving 483 adults.
Nicotine and Caffeine Withdrawal may Lead to Unnecessary Suffering and Testing in Intensive Care Patients: Study
Nicotine and Caffeine Withdrawal may Lead to Unnecessary Suffering and Testing in Intensive Care Patients: Study

The findings are being presented at this year's Euroanaesthesia congress (the annual meeting of the European Society of Anaesthesiology) in Vienna, Austria (1-3 June).

Show Full Article


"Withdrawal symptoms including nausea, vomiting, headaches, and delirium can last for up to 2 weeks. These symptoms resemble conditions such as meningitis, encephalitis, and intracranial haemorrhage--this may confuse clinical diagnosis and result in unnecessary tests which can cause patient harm, cost a lot of money, and waste time."

In Europe, up to 27% of the population smokes, and more than half drink coffee. The systematic review, synthesising all the available evidence from the scientific literature, included 12 studies investigating withdrawal symptoms and treatment in ICUs between 2000 and 2018, involving 483 adults (aged 18-93).

Results showed that acute nicotine withdrawal substantially increases agitation (64% smokers vs 32% non-smokers) and the number of tracheal tube and intravenous line displacements caused by agitation in ICU patients (14% smokers vs 3% non-smokers).

However, nicotine substitution therapy was shown to contribute to the development of ICU delirium (severe confusion and disorientation)--which is associated with prolonged intubation, increased length of stay, and greater risk of dying.

Abrupt caffeine withdrawal leads to drowsiness, nausea, vomiting, headaches, and can increase rates of ICU delirium. Caffeine benzoate has been successfully used to treat headaches but substitution in the ICU has a limited evidence base.

"ICU patients may benefit from nicotine substitution or caffeine supplementation, but with little evidence for their effectiveness, this should be left up to the judgement of treating physicians", says Professor Belitova. "There is lack of evidence on abrupt caffeine withdrawal, its complications and therapeutic options. Future research should focus on acute caffeine withdrawal as an independent risk factor for agitation and delirium in ICU and on available treatment options."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Premium Membership Benefits

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive