An antidote developed specifically for dabigatran successfully reversed the effects of the anti-clotting medication in healthy volunteers, according to research presented at the American Heart Association's Scientific Sessions 2013. New oral anti-clotting medications such as dabigatran (Pradaxa) are easier to take than warfarin. However, up until now, there have been no specific antidotes available to reverse the effects of these new anti-clotting medications when managing life-threatening bleeding or performing emergency surgery. This study shows some promise for an antidote for dabigatran. Researchers developed an antibody fragment (Fab) that specifically binds dabigatran and prevents it from inhibiting clot formation. Fab was given as 1 hour or 5-minute infusions to 145 healthy male volunteers. Immediate, complete and sustained reversal of dabigatran-induced anticoagulation was observed.The antidote is still under development and is not yet approved for clinical use, researchers said. Source: Eurekalert << Beta-Blockers Before Surgery Associated With Lower Risk of ... Selfie: the 2013 Word of the Year >> Recommended Reading Vitamin B2 (riboflavin) is an Antidote to Cyanide Poisoning: Research After the remains of a recent lottery winner was exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. READ MORE Scientists Discovered a Better Cyanide Antidote for Terrorist Attacks Scientists are reporting discovery of a promising substance in an advance toward closing a major gap in defenses against terrorist attacks and other mass casualty events. READ MORE New Antidote May Reverse Effects of Cyanide Toxicity In fire victims, smoke inhalation is the major cause of death due to cyanide poisoning. READ MORE Differences Exist in Stocks of Essential Antidotes at UK Hospitals There is "substantial variation" in the stocks of essential antidotes used to treat various types of life threatening poisoning incidents in UK acute hospitals, finds research READ MORE Drug Toxicity Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. READ MORE Healthy Gifting Ideas for Diwali Diwali, the festival of lights is round the corner. Take a fat free route when it comes to gifting this Diwali. Go the untraditional way and gift your near and dear ones with the gift of health. READ MORE Most Popular on Medindia Drug Side Effects Calculator Blood Pressure Calculator Daily Calorie Requirements More News on: Drug ToxicityHealthy LivingHealthy Gifting Ideas for Diwali
An antidote developed specifically for dabigatran successfully reversed the effects of the anti-clotting medication in healthy volunteers, according to research presented at the American Heart Association's Scientific Sessions 2013. New oral anti-clotting medications such as dabigatran (Pradaxa) are easier to take than warfarin. However, up until now, there have been no specific antidotes available to reverse the effects of these new anti-clotting medications when managing life-threatening bleeding or performing emergency surgery. This study shows some promise for an antidote for dabigatran. Researchers developed an antibody fragment (Fab) that specifically binds dabigatran and prevents it from inhibiting clot formation. Fab was given as 1 hour or 5-minute infusions to 145 healthy male volunteers. Immediate, complete and sustained reversal of dabigatran-induced anticoagulation was observed.The antidote is still under development and is not yet approved for clinical use, researchers said. Source: Eurekalert << Beta-Blockers Before Surgery Associated With Lower Risk of ... Selfie: the 2013 Word of the Year >> Recommended Reading Vitamin B2 (riboflavin) is an Antidote to Cyanide Poisoning: Research After the remains of a recent lottery winner was exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. READ MORE Scientists Discovered a Better Cyanide Antidote for Terrorist Attacks Scientists are reporting discovery of a promising substance in an advance toward closing a major gap in defenses against terrorist attacks and other mass casualty events. READ MORE New Antidote May Reverse Effects of Cyanide Toxicity In fire victims, smoke inhalation is the major cause of death due to cyanide poisoning. READ MORE Differences Exist in Stocks of Essential Antidotes at UK Hospitals There is "substantial variation" in the stocks of essential antidotes used to treat various types of life threatening poisoning incidents in UK acute hospitals, finds research READ MORE Drug Toxicity Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. READ MORE Healthy Gifting Ideas for Diwali Diwali, the festival of lights is round the corner. Take a fat free route when it comes to gifting this Diwali. Go the untraditional way and gift your near and dear ones with the gift of health. READ MORE Most Popular on Medindia Drug Side Effects Calculator Blood Pressure Calculator Daily Calorie Requirements More News on: Drug ToxicityHealthy LivingHealthy Gifting Ideas for Diwali
