About My Health Careers Internship MedBlogs Contact us
Medindia
LOGIN REGISTER
Advertisement

New Weapon Against Cancer Discovered

by Colleen Fleiss on March 13, 2019 at 8:28 AM
Font : A-A+

New Weapon Against Cancer Discovered

The expression of marker genes that are linked to a fingerprint of cancer cells in thousands of tumors revealed its therapeutic potential in the cancer fight, said a research team led by Nuno Barbosa Morais, group leader at Instituto de Medicina Molecular João Lobo Antunes (iMM) in Lisbon.

The study published today in the scientific journal PLoS Computational Biology shows the types of tumors in which these genes are most active and identifies drugs with the potential to selectively eliminate cells that carry that label.

Advertisement


The centrosome is an organelle present in all animal cells that is fundamental in several cellular processes, such as division, migration and communication between cells. For more than a century it has been proposed that the abnormal increase in the number of these structures could induce cancer and since then, the increase in the number of centrosomes is seen as one of the hallmarks of cancer cells and is the subject of the scientists' attention.

The technical difficulties in characterising this abnormality in patient samples have prevented its clinical potential and being explored on a large scale. To bypass this, the team led by Nuno Barbosa Morais at iMM looked at the expression of genes that cause this increase and analysed its incidence in thousands of tumors of different types of cancer and in normal tissue samples from the same patients. "The results revealed that this signature is present only in tumor samples and is more prevalent in aggressive forms of cancer," explains Nuno Barbosa Morais, adding "more importantly, a higher expression of these genes is associated with a lower survival rate in different types of cancer. "
Advertisement

Using drug sensitivity studies, the scientists also identified selective compounds for cells with this abnormality that could be targeted specifically against cancer cells, not affecting the healthy cells of patients. "Additionally, the samples that we have analysed are now characterised at the levels of their DNA sequence and the expression of thousands of genes. This means that the integration of this data allows us to better understand the causes and molecular consequences of this increase of centrosomes in our cells", explains Bernardo de Almeida, the first author of this study.

"The next steps are now to translate the expression data of the genes that cause this "fingerprint" into support information for clinical decision. We also intend to validate the efficacy of the drugs identified by our computational approach as having greater therapeutic potential. These are studies that will naturally involve collaborations with colleagues who are specialists in clinical oncology and pharmacology", says Nuno Barbosa Morais, group leader and supervisor of the study.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Emotional Healing
Psychosis Risk Related to Cat Parasite
Sedentary Behavior Precipitates Night-Time Hot Flashes
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Cancer Must Know Facts
A list of Must Know Top 12 Cancer Facts of the World....
Quiz on Cancer
Cancer, is the second most leading cause of death worldwide. Cancer is not just one disease but ......
Cancer Prevention thro' Lifestyle Changes
Did u know that simple changes in lifestyle could lower your cancer risks? Find out how!...
Hereditary Breast and Ovarian Cancer
Have a history of cancers running in the family? It may be the genes. Find out your risk of ......
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use