About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Way to Make Drug Testing More Efficient Devised

by Colleen Fleiss on February 11, 2018 at 1:09 AM
Font : A-A+

New Way to Make Drug Testing More Efficient Devised

New device created by McMaster University engineers could make drug testing more affordable and to speed up the discovery of new drugs. In addition, to help address the surge of antibiotic resistance, the technology can also help to more quickly identify "helper drugs" that can make even drug-resistant bacteria susceptible to our current antibiotics.

Chemical Engineering Associate Professor Todd Hoare and Rabia Mateen, a PhD candidate in Biomedical Engineering have devised printed paper-based device to speed up drug screening process and could also be used to diagnose diseases, identify environmental contaminants and pinpoint biological warfare agents, was published in Nature Communications in February.

Advertisement


Currently, drug testing is done in multiple stages, with the first stage involving testing thousands of drug candidates in rapid succession to see how well they bind, block or degrade a molecule of interest to the target disease. Subsequent stages involve more extensive testing of drugs that show promise in this first step.

However, the way this initial first screen is now done results in many inaccurate results, with as many as 95% of drug candidates having no chance of becoming a useful drug. In most cases, these inaccuracies arise from the candidate drugs sticking together during the screen to create particles that physically, instead of chemically, block the activity of the molecule targeted by the drug. Such inaccuracies are only now discovered in the slower and more expensive second stage of screening, resulting in significant time and money wasted during the drug discovery process.
Advertisement

Hoare and Mateen have come up with a way to improve the first stage of testing by using a new printable hydrogel, a network of polymers used in everything from contact lenses to disposable diapers. The thin layers of printed hydrogels can form a cage around the target molecule so drug particles formed can't access the target molecule and trigger the inaccurate result. Instead, only drugs that chemically bind to the target molecule (the ones that could become practical drugs) are allowed into the hydrogel to give a positive result. The printed device developed is inexpensive and can be used directly in drug screening, improving accuracy without requiring a significant change in how drug screening is now done. As an added benefit, the same sensitivity can be achieved using much less sample volume, further reducing the cost of the screen.

"We had already developed the printing method, but were not sure what to do with the materials," Mateen said. "Reading about this significant issue in the area of drug screening made me realize that these materials could directly address this problem in a simple and effective way." "As the next step, we are looking for industry partners to prove the effectiveness of our technology on a full-scale screen of thousands of molecules that can help to extend the lifetime of our current antibiotics," Hoare said. "We are optimistic this approach can help to bring new effective drugs to patients faster than is currently possible".

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Drugs Banned in India 

Recommended Reading
Antibiotics
Antibiotics are among the most used and abused medications. This article explains some general ......
Natural Antibiotics to Fight Bacterial Infections
Fighting infections the natural way and preventing them is always more effective than consuming ......
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or ......
Drug Abuse Screening Test
Drug Abuse Screening Test (DAST) is a screening test to find out if you need professional help with ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use