About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Vistas In Cancer Treatment: Cell Disintegration Mechanism Identified

by Gopalan on March 31, 2011 at 8:58 AM
Font : A-A+

 New Vistas In Cancer Treatment: Cell Disintegration Mechanism Identified

New vistas could have been opened up in cancer treatment following the discovery of the mechanism of cell disintegration by researchers with the University of Queensland, Australia.

Professor Alpha Yap and Sabine Mangold of the Institute for Molecular Bioscience at the varsity have been studying how cells stick together and the diseases that occur when cells detach. The progression of tumours to advanced stages commonly occurs when cancer cells separate from their tissue of origin.

Advertisement

"We examined a protein called HGF that is often found in cancer," Ms Mangold said.

"HGF regulates cell growth, shape and movement and aids cancer cells in migrating to other tissues and spreading through the body.

"Scientists have long known that HGF disrupts the junctions where cells join together, but the exact mechanism of how this occurs hasn't been understood until now."
Advertisement

The team made by their discovery by examining the molecular machinery that binds cells. One key component is a protein called E-cadherin, which forms the adhesive to hold cells together.

E-cadherin associates with a scaffold found inside the cells, made of a protein called actin. Normally, actin links into a meshwork with cadherin to make strong contacts between cells.

Ms Mangold and Professor Yap found that the actin scaffolding seemed to be lost just as the cell contacts became disrupted. They discovered this occurred because HGF caused another protein, Myosin VI - which normally acts to link cadherin and actin together - to be lost from cadherin.

"So HGF was causing this interlinked meshwork of proteins to come apart, breaking up the system and causing cells to drift apart," Professor Yap said.

"The discovery of this pathway may open new avenues to understand exactly how proteins that bind cells together are affected in disease, which could lead to new targets for treatments of such disease, including cancer."



Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Parkinsons Disease Surgical Treatment Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Most Popular on Medindia

Sanatogen Find a Doctor A-Z Drug Brands in India Calculate Ideal Weight for Infants The Essence of Yoga Iron Intake Calculator Indian Medical Journals Blood - Sugar Chart Blood Donation - Recipients Nutam (400mg) (Piracetam)
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

New Vistas In Cancer Treatment: Cell Disintegration Mechanism Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests