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New Vaccine Against Multiple Influenza Strains Passes First Test

by Tanya Thomas on Aug 25 2008 10:12 AM

 New Vaccine Against Multiple Influenza Strains Passes First Test
Researchers at the University of Texas, Galveston developed a new vaccine which can fight several strains of the influenza virus. They have now reported that the vaccine has passed the first phase of testing.
Dr. Christine Turley, director of clinical trials and clinical research at the Sealy Center for Vaccine Development at UTMB and the study's principal investigator, said that VaxInnate's M2e universal vaccine could possibly protect against seasonal and pandemic influenza strains.

"We'd characterize this influenza vaccine candidate as very promising, based upon the immune responses and tolerability we saw in the clinical trial participants," Turley said.

"UTMB is committed to further studies of the vaccine candidate, which has the potential to be a safe, highly effective and much-needed option to prevent seasonal and pandemic influenza A," Turley added.

For the trial, researchers recruited 60 young adults in a double-blind, dose-escalating, first time in human, Phase I study to assess the safety and immunogenicity, or the ability to produce a response in the immune system, of the vaccine.

The trial was also designed to evaluate the methods used by VaxInnate to develop and produce flu vaccines.

The company uses a proprietary combination of toll-like receptor-mediated immune enhancement and recombinant bacterial production of vaccine antigen.

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This proprietary technology could significantly decrease the time required to produce vaccine supplies sufficient to meet national demand, and provide a solution to international influenza vaccine needs which are unmet in all but the developed world.

The study will be presented at the Oct.25-28 joint meeting of the Interscience Conference on Agents and Chemotherapy and the Infectious Disease Society of America (ICAAC/IDSA).

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Source-ANI
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