New Treatment for Age-related Macular Degeneration

by Hannah Joy on  March 20, 2018 at 11:46 AM Genetics & Stem Cells News
RSS Email Print This Page Comment bookmark
Font : A-A+

A specially engineered retinal patch has been developed that helps treat people with age-related macular degeneration (AMD), reveals a new study.

In July 2015, 86-year-old Douglas Waters developed severe AMD. He struggled to see things clearly, even when up close.
New Treatment for Age-related Macular Degeneration
New Treatment for Age-related Macular Degeneration

A few months later, he became part of a clinical trial that used stem cell-derived ocular cells developed in part by researchers at UC Santa Barbara. His retinal eyepatch was implanted at Moorfields Eye Hospital, a National Health Service (NHS) facility in Waters' hometown of London, England.

Show Full Article


In the months before Waters' surgery, his vision was poor and he couldn't see anything out of his right eye. After the surgery, his eyesight improved so much that he could read the newspaper and help his wife with gardening.

The results of this groundbreaking clinical study, published in Nature Biotechnology, describe the safe and effective implantation of a specially engineered patch of retinal pigment epithelium cells derived from stem cells to treat people with sudden severe sight loss from wet AMD the form that afflicted Waters. This is the first description of a completely engineered tissue that has been successfully used in this way.

"This study represents real progress in regenerative medicine and opens the door on new treatment options for people with age-related macular degeneration," said co-author Peter Coffey, a professor at UCSB's Neuroscience Research Institute and co-director of the campus's Center for Stem Cell Biology & Engineering.

Age Related Macular Degeneration (AMD) accounts for almost 50 percent of all visual impairment in the developed world and usually affects people over 50 years of age. AMD affects the central (reading) vision while leaving the surrounding vision normal.

Wet AMD is generally caused by abnormal blood vessels that leak fluid or blood into the region of the macula in the center of the retina and almost always begins as dry AMD. Researchers hope the new procedure will also help in the future to treat dry AMD.

The study investigated whether the diseased cells at the back of the patients' affected eye could be replenished using the stem cell patch. A specially engineered surgical tool was used to insert the patch under the retina in the affected eye of each patient in an operation lasting one to two hours.

In addition to Waters, a woman in her early 60s who also suffered from a severe form of wet AMD and declining vision underwent the procedure. She and Waters were monitored for 12 months and reported improvements to their vision. They went from not being able to read at all even with glasses to reading 60 to 80 words per minute with normal reading glasses.

"We hope this will lead to an affordable 'off-the-shelf' therapy that could be made available to NHS patients within the next five years," said Coffey, who founded the London Project to Cure Blindness more than a decade ago.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Premium Membership Benefits

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive