A new segmented RNA virus discovered by researchers in northeastern China is linked to febrile illness in dozens of patients. Researchers have suspected that the virus is transmitted by ticks. The findings of the study are published in The New England Journal of Medicine.
They named the previously unknown pathogen the Alongshan virus (ALSV). It should be differentiated from other tick-borne diseases, such as severe fever with thrombocytopenia syndrome, tick-borne encephalitis, anaplasmosis, rickettsiosis and babesiosis.
In 2017, surveillance for tickborne diseases in China led to the identification of a patient who presented to a hospital in Inner Mongolia with a febrile illness that had an unknown cause. The clinical manifestation of the illness was similar to that of tickborne encephalitis virus (TBEV) infection, but neither TBEV RNA nor antibodies against the virus were detected.
We found that the index patient was infected with a previously unknown segmented RNA virus, which we designated Alongshan virus (ALSV) and which belongs to the jingmenvirus group of the family Flaviviridae. ALSV infection was confirmed by RT-PCR assay in 86 patients from Inner Mongolia and Heilongjiang who presented with fever, headache, and a history of tick bites. Serologic assays showed that seroconversion had occurred in all 19 patients for whom specimens were available from the acute phase and the convalescent phase of the illness.