About Careers MedBlog Contact us

New Therapy to Prevent Triple Negative Breast Cancer from Spreading

by Ramya Rachamanti on April 18, 2019 at 7:59 PM
Font : A-A+

New Therapy to Prevent Triple Negative Breast Cancer from Spreading

Combination drug therapy targeting an essential protein called p53 could decrease the spread of triple negative breast cancer to other locations of the body by 50 percent, according to the team of researchers from the University of Missouri.

Protein p53 suppresses and kills cancer in people. But, a defective, mutant form of p53 helps cancer cells grow and multiply.


"Most people who succumb to breast cancer, and those in particular with triple-negative breast cancer, do so following metastasis, or spread of the cancer to other organs in the body," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center. "Triple negative breast cancer lacks ways to treat the cancer with chemotherapy. Therefore, people are administered toxic, non-specific drugs. We wanted to see if this combination therapy could provide a new, non-toxic targeted approach for treatment."

The study built on previous research by Hyder's lab and used mice that had human metastatic cancer, which had spread into the lungs. Researchers wanted to see if two previously discovered drugs -- APR-246 that restores the p53 protein's ability to kill cancer cells and 2aG4 that targets the blood vessels in order to kill cancer cells -- had an effect on metastatic triple negative breast cancer. Hyder says the results are promising.

"The number of metastatic colonies was reduced when both compounds were given separately, and a little more with the combination of the two," Hyder said. "More importantly, the incidents of breast cancer, that is the number of mice that got cancer, was reduced by 50 percent when both were combined."

Both APR-246 and 2aG4 are currently in human clinical trials. Researchers hope these findings will help enhance personalized treatment for breast cancer by reducing existing cancer cells and preventing the spread of the cancer to other parts of the body.

This research highlights the power of translational precision medicine and the promise of the proposed initiative at MU. The initiative will bring together industry partners, multiple schools and colleges on campus, and the federal and state government to enable precision and personalized medicine.

Scientific advancements made at MU will be effectively translated into new drugs, devices and treatments that deliver customized patient care based on an individual's genes, environment and lifestyle, ultimately improving health and well-being of people.

Source: Eurekalert


Recommended Reading

Latest Cancer News

Two Years: Optimal Duration of Immunotherapy in Advanced Lung Cancer
Study suggests two-year immunotherapy treatment for advanced lung cancer may be reasonable
Hope for Lethal Brain Tumors: Targeted Therapy Delays Glioma Progression
A ray of hope for glioma patients as targeted therapy boosts treatment duration.
Is Adding Ribociclib to Hormone Therapy Improves Breast Cancer Outcomes
In patients with breast cancer combination therapy had increased invasive disease-free survival compared to those who were treated with the hormone therapy alone.
Antibody Treatment Proves Effective for Bile Duct Cancers
An antibody treatment helped shrink tumors in some patients with bile duct cancers.
Link Between Gut Microbiome and Precancerous Colon Polyps Identified
Comprehending the association between the gut microbiome and polyp growth sheds insights into potential screenings and treatments.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

New Therapy to Prevent Triple Negative Breast Cancer from Spreading Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests