About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Therapy Target for Drug-induced Liver Failure Discovered

by Colleen Fleiss on April 7, 2019 at 11:09 PM
Font : A-A+

New Therapy Target for Drug-induced Liver Failure Discovered

Therapies that boost the levels of protein thrombospondin-1 could help the liver recover from an overdose of acetaminophen, suggested new study.

"The only treatment available now for acetaminophen overdose must be administered early, before significant liver injury occurs," said Matthew McMillin, PhD, who performed the research. "We are working to identify new drug targets to improve treatment options and reduce the need for liver transplantation, which is often the only option for patients with acute liver failure due to drug toxicity."

Advertisement


McMillin, an assistant professor at the University of Texas at Austin and research biologist at Central Texas Veterans Health Care System, will present the research at the American Society for Investigative Pathology annual meeting during the 2019 Experimental Biology meeting to be held April 6-9 in Orlando, Fla.

McMillin and his colleagues found that mice with acute liver failure from acetaminophen toxicity had higher levels of thrombospondin-1 than mice with normal liver function. When they administered acetaminophen to genetically modified mice that lack thrombospondin-1, the liver injury and loss of liver function was more severe compared to unmodified mice. The researchers also observed impaired liver regeneration and increased cell death in the mice without thrombospondin-1.
Advertisement

"Our study is the first to investigate thrombospondin-1 during acetaminophen toxicity," said McMillin. "We were able to identify cell communication pathways that do not work properly during acetaminophen-induced liver injury and thus lead to worse outcomes." Next, the researchers plan to give mice different drug treatments that manipulate thrombospondin-1 to find out which treatment might be suited for potential clinical studies. They also plan to examine patients with acetaminophen-induced acute liver failure to determine if their thrombospondin-1 findings from mice hold true in people.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alcoholic Liver Disease Hepatitis A Reiki and Pranic Healing Liver Wilson's Disease Milk Thistle Current Treatments for Liver Cancer Fatty Liver Disease: A Growing Health Problem in India Living Donor Liver Transplant: What Are the Risks? Budd-Chiari Syndrome 

Recommended Reading
Liver Failure
Liver failure occurs when the liver loses its ability to perform its normal functions of ......
Quiz on Liver
How many of us know that the liver is a vital organ the size of an American Football? To understand ...
‘Lab-Grown Liver’ Offers New Hope for Acute Liver Failure Patients
'Lab-Grown Liver' offers fresh hope for patients suffering from acute liver failure (ALF)....
Acetaminophen or Paracetamol
Acetaminophen or paracetamol helps to reduce fever and to relieve a headache with mild to moderate ....
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver ......
Budd-Chiari Syndrome
Budd-Chiari Syndrome (BCS) is a rare disorder caused by narrowing and obstruction (occlusion) of the...
Current Treatments for Liver Cancer
Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result ...
Fatty Liver Disease: A Growing Health Problem in India
Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is...
Hepatitis A
Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. H...
Living Donor Liver Transplant: What Are the Risks?
The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk ...
Milk Thistle
Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication ...
Wilson's Disease
This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before o...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use