Anti-microRNAs were found to be the possible new therapeutic target for type 2 diabetes, said researchers.

‘In vivo silencing of microRNA-132 with antagomirs could be used as therapeutic intervention for diabetes, improving insulin secretion and decreasing blood glucose. ’

"In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion" is the title of the article coauthored by Roel Bijkerk, Johanne Ellenbroek, Yu Wah Au, Maaike Hanegraaf, Eelco de Koning, and Anton Jan van Zonneveld, Leiden University Medical Center, The Netherlands and Jonathan Esguerra and Lena Eliasson, Lund University and SIS Malmö, Malmö, Sweden. 




The researchers treated mice systemically, and mouse and human islets with an agonist designed to block the expression of microRNA-132, called antagomir-132. They reported that blood glucose levels remained low in treated mice for three days following the injection of antogamiR-132. The authors encourage additional studies of this new treatment approach in additional animal models of type 2 diabetes.
Source-Eurekalert