About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Therapeutic Target For High Blood Pressure Identified

by Gopalan on January 16, 2011 at 10:28 AM
Font : A-A+

 New Therapeutic Target For High Blood Pressure Identified

US researchers claim to have identified a new therapeutic target for high blood pressure treatment - the nephrons.

These basic structural units of the kidney, numbering roughly a million, remove waste products from the blood, recycle some substances to be reused and eliminate what is left as urine. The end segment of nephrons, called the distal nephron, helps set blood pressure by controlling the amount of sodium in our blood.

Advertisement

Now scientists at The University of Texas Health Science Center San Antonio have reported how this essential function of the distal nephron is regulated. They demonstrated that sodium handling by the distal nephron is under the control of a local regulatory system.

Loss or dysfunction of this system leads to hypertension resulting from improper salt retention by the kidneys, the scientists found in mouse studies.
Advertisement

"These studies provide the first unequivocal evidence of a blood pressure control system in the distal nephron of the kidney," said senior author James Stockand, Ph.D., professor of physiology at the Health Science Center. "It turns out control of sodium re-absorption by this system is as important to normal blood pressure regulation as is a better-understood system, called the renin-angiotensin-aldosterone system, which works outside the kidney."

Many medications that treat high blood pressure target salt handling in the kidney. "Our work identifies a possible new therapeutic target," Dr. Stockand said.

The research was funded by the U.S. National Institutes of Health and American Heart Association and included colleagues at the University of Southern California. The findings are in the Jan. 14 issue of the Journal of Biological Chemistry.



Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
High Blood Pressure Thalassemia Diet Lifestyle and Heart Disease Diet and High Blood Pressure Stress and the Gender Divide Stroke Quiz on Hypertension Heart Attack- Lifestyle Risks Can Garlic Control High Blood Pressure High Blood Pressure and Herbs 

Most Popular on Medindia

Calculate Ideal Weight for Infants The Essence of Yoga Selfie Addiction Calculator A-Z Drug Brands in India Post-Nasal Drip Sinopril (2mg) (Lacidipine) Drug Interaction Checker Pregnancy Confirmation Calculator How to Reduce School Bag Weight - Simple Tips Accident and Trauma Care
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

New Therapeutic Target For High Blood Pressure Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests