Metabolomic analysis - a new diagnostic test could be a safe and easy screening method to detect pancreatic cancer, say researchers.
The researchers examined the utility of metabolomic analysis as a diagnostic method for pancreatic cancer and then validated the new approach.
Pancreatic Cancer
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
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Masaru Yoshida, M.D., Ph.D., associate professor and chief of the Division of Metabolomics Research at Kobe University Graduate School of Medicine in Kobe, Japan, said that although surgical resection can be a curative treatment for pancreatic cancer, more than 80 percent of patients with pancreatic cancer have a locally advanced or metastatic tumor that is unresectable at the time of detection.
Using gas chromatography mass spectrometry, they measured the levels of metabolites in the blood of patients with pancreatic cancer, patients with chronic pancreatitis and healthy volunteers.
![Quiz on Pancreas]( "Quiz on Pancreas")
Pancreas is both an endocrine and an exocrine organ. It secretes insulin, which is required for sugar breakdown. To learn more about the unique functions of the pancreas, engage in the following quiz.
The scientists randomly assigned 43 patients with pancreatic cancer and 42 healthy volunteers to a training set and 42 patients with pancreatic cancer and 41 healthy volunteers to a validation set. They included all 23 patients with chronic pancreatitis in the validation set.
Analysis of the metabolomic data generated from the training set indicated that levels of 18 metabolites were significantly different in the blood of patients suffering from pancreatic cancer compared with other volunteers.
Further investigation led them to develop a method to predict a pancreatic cancer diagnosis using assessment of the levels of just four metabolites.
In the training set, the approach demonstrated 86 percent sensitivity and 88.1 percent specificity. When tested again in the validation set that included patients with chronic pancreatitis, the method demonstrated 71.4 percent sensitivity and 78.1 percent specificity.
Yoshida said that their diagnostic approach using serum metabolomics possessed higher accuracy than conventional tumor markers, especially at detecting the patients with pancreatic cancer in the cohort that included the patients with chronic pancreatitis.
"This novel diagnostic approach, which is safe and easy to apply as a screening method, is expected to improve the prognosis of patients with pancreatic cancer by detecting their cancers early, when still in a resectable and curable state," he said.
The study has been published in Cancer Epidemiology, Biomarkers and Prevention.
Source: ANI
Quiz on Pancreas
Pancreas is both an endocrine and an exocrine organ. It secretes insulin, which is required for sugar breakdown. To learn more about the unique functions of the pancreas, engage in the following quiz.
Advertisement
The scientists randomly assigned 43 patients with pancreatic cancer and 42 healthy volunteers to a training set and 42 patients with pancreatic cancer and 41 healthy volunteers to a validation set. They included all 23 patients with chronic pancreatitis in the validation set.
Analysis of the metabolomic data generated from the training set indicated that levels of 18 metabolites were significantly different in the blood of patients suffering from pancreatic cancer compared with other volunteers.
Further investigation led them to develop a method to predict a pancreatic cancer diagnosis using assessment of the levels of just four metabolites.
In the training set, the approach demonstrated 86 percent sensitivity and 88.1 percent specificity. When tested again in the validation set that included patients with chronic pancreatitis, the method demonstrated 71.4 percent sensitivity and 78.1 percent specificity.
Yoshida said that their diagnostic approach using serum metabolomics possessed higher accuracy than conventional tumor markers, especially at detecting the patients with pancreatic cancer in the cohort that included the patients with chronic pancreatitis.
"This novel diagnostic approach, which is safe and easy to apply as a screening method, is expected to improve the prognosis of patients with pancreatic cancer by detecting their cancers early, when still in a resectable and curable state," he said.
The study has been published in Cancer Epidemiology, Biomarkers and Prevention.
Source: ANI
Research Probes How Pancreatic Cancers Metastasize
Researchers have discovered that a protein found in the cells surrounding pancreatic cancers play a role in the spread of the disease to other parts of the body.
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 New Cheap Tool Developed for Early Detection of Pancreatic CancerUS teenager Jack Andraka developed a new easy way to detect cancer in an organ before it progresses to an advanced stage | Advertisement
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