Researchers at Oregon Health and Science University have developed a technique to turn a mouse into a factory for human liver cells. The new development can be used to test how pharmaceuticals are metabolised in the organ so as to determine drugs' toxicity. The researchers claim that their technique also offers a platform for testing new therapies against infectious diseases that attack the liver, such as hepatitis C and malaria. "This has the potential, if it becomes easy to use and widely available, to change the way drugs are tested," Nature magazine quoted study leader Dr. Markus Grompe, Professor of Molecular and Medical Genetics, and Paediatrics, as saying. "In terms of fostering research, this will be great for malaria, this will be great for hepatitis, this will be great for liver stem cells, this will be great for gene therapy. It will allow a lot of what's going on only in rodents to be taken into a much more clinical setting. So I'm very happy about it," he added. Arundeep S. Pradhan, the Director of OHSU's Technology & Research Collaborations office, says that the demand for Grompe's discovery is very high in the market. The university has filed a patent application on the technology, and formed a new company in Portland called Yecuris through its Springboard Program. "Yecuris is a viable start-up company based on significant developments at OHSU. The products developed by Yecuris have the potential to ease one of the bottlenecks in drug development: the testing of drugs for liver toxicity," Pradhan said. Since the liver is the principal site for the metabolism of drug compounds, the worldwide market for human liver cells used by the pharmaceutical industry for testing candidate drug compounds is estimated at two billion dollars a year, according to a business plan for Yecuris. "Chemicals are converted to other chemicals in the liver, and you can't predict how the compound you developed in the lab will be converted. Often, it's not the drug that's toxic, but the resulting metabolites. The conversion of drugs cannot be predicted with any current technology, such as computer models. You actually have to see what human liver cells do with any given drug," Grompe said. His laboratory has now created a severely immunodeficient mouse strain that develops liver disease only when the animals do not receive a protective drug called NTBC, allowing liver disease to be turned on and off. "Our mice on this medicine are perfectly healthy, normal mice, and only when we take them off the NTBC do they get liver disease. It's an easy system that any research lab should be able to set up, which is very different from what's around now," Grompe said. The human liver cells from the repopulated mouse livers are indistinguishable from normal human liver cells. "The healthy human liver cells take over and replace the sick mouse liver cells. You end up with a healthy mouse that makes human blood clotting factors, all the proteins the liver makes, human bile, everything," Grompe said. Each mouse can be implanted with human liver cells at least four times, and each round of implantation can generate over 20 million viable human liver cells. "We think we will have a real edge in terms of quality and availability of cells. We have a product. All we need to do is scale up and start selling it to anyone who wants to buy it," Grompe said. Source: ANISRM/J << NGO Launches Anti-obesity Campaign in Chandigarh Sabotage at the Heart of UK Bio-terrorism Threat >> Recommended Reading Hepatitis B Hepatitis B is inflammation of the liver due to infection with the hepatitis B virus. READ MORE Math Model Helps Identify Genes That Attack Hepatitis C Virus Researchers have developed a mathematical model that identifies genes that battle the hepatitis C virus, which attacks the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Sinopril (2mg) (Lacidipine) Color Blindness Calculator Pregnancy Confirmation Calculator More News on: Hepatitis AParkinsons Disease Surgical TreatmentLiverWilson's DiseaseMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?