Medindia
Advertisement

New Tau-based Vaccines Could Transform Early Alzheimer’s Disease Treatment

by Vishnuprasad on January 28, 2015 at 7:40 PM

New Tau-based Vaccines Could Transform Early Alzheimer’s Disease Treatment
While current treatments for Alzheimer's Disease (AD) are only able to ease symptoms temporarily, tau-based vaccines may offer a new and more effective way to treat AD in the early course of the disease, says an analyst with research and consulting firm GlobalData.

According to Kyle S. Nicholson, PharmD, GlobalData's Analyst covering Neurology, tau-based therapies for AD have traditionally been overlooked in favor of passive beta amyloid immunotherapies, such as Eli Lilly's solanezumab and Roche's gantenerumab and crenezumab.
Advertisement

However, this interest appears to be receding after notable setbacks in recent years, and tau-based immunotherapies now have the potential to capture larger patient shares than these products.

Nicholson explains: "Tau is one of two peptides linked to AD, and is known for forming tangles of neuronal fibers inside the brain and causing cellular death. The other abnormal protein believed to cause damage that leads to AD is beta amyloid."
Advertisement

"Doubts are starting to arise over whether or not the removal of beta amyloid will affect a patient's cognitive status. Given that tau-related pathology might occur before beta amyloid becomes implicated, a tau-based approach may have a greater chance of eliciting measurable effects earlier in the disease's progression."

The analyst notes that Johnson & Johnson and AC Immune have already entered into a three-year agreement to develop and commercialize tau-based immunotherapies for AD. These include ACI-35, which is currently in Phase IIb trials and positioned to be the first-in-class phosphorylated tau proteins vaccine inhibitor.

However, Nicholson adds: "Despite its potential first-in-class status, ACI-35 will encounter significant competition from disease-modifying passive immunotherapies and oral beta-secretase inhibitors, which will start populating the market in 2018."

"We expect AstraZeneca/Eli Lilly's AZD-3293 and Merck & Co.'s MK-8931 to capture over 15% of the global AD space by 2023. ACI-35 will therefore likely enter a highly competitive arena several years after the beta amyloid therapies have already taken a significant patient share," the analyst concludes.  



Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Vaccination for Children Common Lifestyle Habits that Cause Diseases Dementia Top 10 Vaccine Myths Debunked 

Recommended Reading
Creutzfeldt-Jakob Disease
Creutzfeldt-Jakob disease (CJD) is a rare form of degenerative brain disorder, or brain damage that ...
Diet and Alzheimer´s Disease
Alzheimer''s begins with forgetfulness, but over time affects speech and coordination along with ......
Therapies That Reduce Apolipoprotein E may Have the Potential to Treat Alzheimer’s Disease
Researchers suggest that therapies that can reduce the levels of apolipoprotein E (apoE) could have ...
Anti-Aging Protein can Slowdown or Prevent Alzheimer’s Disease
Using anti-aging protein Klotho in pretreatment of neurons can prevent neuron death in the presence ...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Dementia
Dementia has become a very big concern as we have an aging population across the world. Dementia is ...
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...
Vaccination for Children
Vaccines are biological products that impart immunity to the recipient. Vaccines may be live attenua...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use