It is very well-known that patients with both type 1 diabetes and CKD have an increased risk of adverse outcomes.
Despite aggressive treatment, many patients with type 1 diabetes and overt nephropathy develop End-Stage Renal Disease (ESRD) and/or succumb to a premature death. The competing risks of death and ESRD may confound the estimates of risk for each outcome.
Now, the researchers at the University of Helsinki, University Hospital of Helsinki and Folkhälsan Research Center, Finland, and at the Queen Elisabeth Hospital and Baker IDI Heart and Diabetes Institute, Australia, have determined the major predictors of the cumulative incidence of ESRD and pre-ESRD mortality in patients with type 1 diabetes and macroalbuminuria while incorporating the competing risk for the alternate outcome into a Fine-Gray competing-risks analysis. This research is appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).
"In our cohort, ESRD was the most likely outcome, potentially driving epidemiologic associations between risk factors and all-cause mortality. By adjusting for these competing risks, we show that poor glycemic control increases the cumulative incidence of ESRD, but is not associated with increased pre-ESRD mortality. By contrast, improved lipid control may affect both ESRD outcomes and pre-ESRD mortality", says Dr. Carol Forsblom from the University of Helsinki and Folkhälsan Research Center.
"This kind of novel statistical approach has the potential to shed new light on the targets and strategies for preventing premature mortality in patients with type 1 diabetes," Dr. Forsblom states.