New Targeted Cancer Therapy Identified

by Hannah Joy on  September 27, 2017 at 5:24 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

Precision medicine is becoming increasingly important in cancer therapy, which serves to the needs of patients individually. Currently, molecular-biological diagnostics can identify alterations in tumor cells, accurately, reveals a new study.
New Targeted Cancer Therapy Identified
New Targeted Cancer Therapy Identified

A major aim of modern cancer therapy is to develop drugs that individually target these altered tumor cells, but do not impact the surrounding healthy cells.

Show Full Article


Scientists in the working groups of Professor Roman Thomas and Professor Martin Sos at the Institute of Pathology and the Department of Translational Genomics of Cologne University Hospital have tested the effects of more than 1,500 substances on different kinds of cancer cells.

The testing procedure was carried out in cooperation with the Technical University of Dortmund, the Lead Discovery Center Dortmund, and other international groups.

The researchers were able to identify an inhibitor that specifically limits the growth of cells exhibiting a fusion of the proteins BRD4 and NUT.

The resulting BRD4/NUT fusion genes are characteristic for so-called NMC tumours. NMC (NUT midline carcinoma) is a rare, aggressive type of cancer affecting the epithelial tissue of mucous membranes in the patient's pharynx and throat. To date there is no effective therapy for this cancer.

In the study, the scientists were able to shed light on the molecular mechanism responsible for the effectiveness of the inhibitor. Their insights are an important prerequisite for the development of new and improved therapies for NMC, which is lethal in most cases.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Premium Membership Benefits

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive