About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER

New Study Support Use of Microbicide Vaginal Gels to Protect from HIV

by VR Sreeraman on July 26, 2008 at 5:19 PM
Font : A-A+

 New Study Support Use of Microbicide Vaginal Gels to Protect from HIV

A new study by a Tulane University research team gives support for the use of vaginal microbicide gels as a way to protect women against sexual transmission of HIV.

The team, led by Ronald S. Veazey, professor of pathology and chair of the Division of Comparative Pathology at the Tulane National Primate Research Center, successfully used vaginal gels containing the fusion inhibitory peptide T-1249 to protect rhesus macaque monkeys against vaginal transmission of multiple strains of simian/human HIV (SHIV). Their report was published online on July 21, 2008 in the Proceedings of the National Academy of Sciences.


The study details the gel's success in protecting macaques from infection by three different strains of SHIV.

"Here we have shown that the vaginal application of gel-formulated T-1249 can protect rhesus macaques from infection by three different SHIV challenge viruses," say the researchers. "The protection we observed was dose-dependent, and at the higher concentration, robust, in that all the test animals resisted infection."

Fusion inhibitors such as T-1249 operate to inhibit infection by preventing glycoprotein molecules on HIV particles from binding to their receptors on the surface of the immune cell. The T-1249 peptide is a fusion inhibitor that targets one of the main cellular receptors that HIV uses to infect cells in the mucosal surface. A major advantage of T-1249 over other compounds is that it targets a receptor common to most strains of HIV.

The team concludes that vaginal microbicide containing fusion inhibitors remain a potential method for protecting women against infection by HIV type 1 during sexual intercourse.

The researchers caution: "Whether T-1249 could be developed as a practical microbicide will depend on whether it can be successfully formulated at a reasonable cost."

Protection against HIV in the real world is also very challenging because of the ever-increasing number of different HIV strains in circulation. "An effective microbicide formulation is, therefore, likely to require the coformulation of more than one entry inhibitor," say the authors.

The research was funded by grants from the National Institutes of Health and Bristol-Meyers Squibb.

Source: Newswise
SRM

News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment Prostitution: Fresh Stakes in the Oldest Trade HIV Symptom AIDS and Pregnancy 

Recommended Reading
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV...
How to use a condom - Animation
This Interactive provides step by step visual aid showing how to correctly use condoms which can ......
Female Condom - Animation
Animation on how to use Female condom and its advantages....
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
AIDS and Pregnancy
The Acquired immune deficiency syndrome is brought about by the deadly human immunodeficiency virus....
AIDS/HIV
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure...
AIDS/HIV - Clinical Features
Encyclopedia section of medindia gives general info about HIV Clinical Features...
AIDS/HIV - Epidemiology
AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with preca...
AIDS/HIV - Health Education
Encyclopedia section of medindia gives general info about AIDS information and health education....
Oral Health And AIDS
AIDS has taken on massive proportions in modern times. It is estimated that over 15 million people a...
Prostitution: Fresh Stakes in the Oldest Trade
Prostitution has broadened its base to include street prostitution, massage brothels, gigolo outcall...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use