About Careers Internship MedBlog Contact us

New Study Raises Hope for Needle-free Diabetes Treatment

by VR Sreeraman on August 12, 2009 at 12:32 PM
Font : A-A+

 New Study Raises Hope for Needle-free Diabetes Treatment

Hopes have been raised of a new treatment to free thousands of diabetes sufferers from the burden of daily needle injections.

Found in 30 percent of all human cancer tumours, the Ras protein literally 'drives cells crazy,' says Prof. Yoel Kloog, the dean of the Faculty of Life Sciences at Tel Aviv University.


Kloog was the first in the world to develop an effective anti-Ras drug against pancreatic cancer, currently in clinical trials.

And now, Kloog's student Adi Mor of TAU's Department of Neuro-biochemistry and Sackler School of Medicine has modified the anti-Ras FTS compound to develop what could be the first tablet-based treatment for children and adults with Type 1 diabetes.

Early results have shown that FTS is effective in restoring insulin production in animal models.

And given the drug's history - FTS has already passed toxicity studies for other diseases and disorders - it has the potential to fast-track through FDA regulatory hurdles, skipping straight to Phase II clinical trials.

A new drug for diabetes could be ready in as little as five years' time.

Previous studies by Kloog's lab found that the FTS compound is effective against autoimmune diseases such as multiple sclerosis and lupus, "but the mechanism of its effects on immune cells was not well understood," says Mor.

"I wanted to see if there was a connection between Ras and the regulation of the immune system, and if so if FTS could help regulate it to prevent or slow diabetes," Mor added.

Through treating cells with the Tel Aviv University FTS compound, Mor was able to find and isolate an important immune system regulator protein called Foxp3.

This protein keeps T cells in the immune system in check. T cells are the immune system's "soldiers" that fight off infection and disease. In her studies in the lab, when Mor blocked Ras using the FTS drug, she was able to increase the Foxp3 protein, which gave a boost to the all-important T cells.

Mor then theorized that if the amount of regulatory T cells in the body was increased, the progression of diabetes would diminish.

"My aim was to slow down diabetes, which brings a suitcase of side-effects like circulatory problems that lead to blindness and amputations," she says.

In her recent study, Mor treated pre-diabetic mice for six months. One group was given FTS, another was given no drug at all.

Only 16 percent of the treated group developed diabetes, while 82 percent of the untreated group became diabetic.

Also, insulin production from beta cells in the treated group of mice increased in comparison to insulin production in the non-treated group, says Mor.

"Since the FTS molecule is very easily absorbed into the blood, it could be the first diabetes treatment in pill form to moderate insulin production in juvenile diabetes, slowing down the progression of the disease. It could help a lot of people," Mor said.

The research has been published in the June issue of the European Journal of Pharmacology.

Source: ANI

News A-Z
What's New on Medindia
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Diabetes Diabetic Diet Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Stress Relief Through Alternative Medicine Stress and the Gender Divide Silent Killer Diseases 

Most Popular on Medindia

Indian Medical Journals Blood Pressure Calculator Blood Donation - Recipients Diaphragmatic Hernia Blood - Sugar Chart Calculate Ideal Weight for Infants Color Blindness Calculator Drug Side Effects Calculator The Essence of Yoga Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

New Study Raises Hope for Needle-free Diabetes Treatment Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests