About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Study on 'Benign' Malaria Could Impact Future Malaria Vaccine Design and Development

by Thilaka Ravi on September 5, 2012 at 6:51 PM
Font : A-A+

New Study on 'Benign' Malaria Could Impact Future Malaria Vaccine Design and Development

Findings from a new study challenge the widely-accepted theory that Plasmodium falciparum, which causes the most lethal form of malaria, is the only malaria parasite capable of driving genome evolution in humans. The study is published in the journal PLOS Medicine.

Professor Ivo Mueller from the Walter and Eliza Hall Institute and Barcelona Centre for International Health Research (CRESIB) led the study, with colleagues from the Papua New Guinea Institute of Medical Research, Centre of Global Health and Diseases, US, and the University of Western Australia.

Advertisement

Malaria is a devastating parasitic disease that kills up to one million people a year. It is a major cause of poverty and a barrier to economic development. Approximately half of the world's population is at risk of malaria infection.

"Humans and malaria parasites have been co-evolving for thousands of years," Professor Mueller said. "Malaria has been a major force in the evolution of the human genome, with gene mutations that provide humans with some protection against the disease being preserved through natural selection because they aid in survival."
Advertisement

Professor Mueller said the study has challenged the perception that P. falciparum malaria is the only malaria species that affects human genome evolution. "It has long been assumed that Plasmodium falciparum, the species that causes the most severe disease and most deaths from malaria, is the most important driver of this gene selection in humans," Professor Mueller said. "Our results suggest that P. vivax malaria, though until recently widely considered to be a 'benign' form of malaria, actually causes severe enough disease to provide evolutionary selection pressures in the Asia-Pacific."

Professor Mueller said that the research team was interested in whether P. vivax malaria might be the cause of the unusually high rates of Southeast Asian ovalocytosis (SAO), a hereditary red blood cell disorder, in the Asia-Pacific region. "SAO occurs in approximately 10 to 15 per cent of the population in parts of the South West Pacific and is caused by a hereditary mutation in a single copy of a gene that makes a red blood cell membrane protein. This is almost an absurdly high frequency when you consider that inheriting two copies of the mutation is invariably fatal, so we figured it must confer a strong advantage to the carriers," he said.

The research team looked at the incidence of P. vivax and P. falciparum infections in three studies that included a total of 1975 children in Papua New Guinea aged 0-14 years. "We found that SAO-positive children were significantly protected against P. vivax infection, with 46 per cent reduction of clinical disease in infants with little or no immunity, and 52-55 per cent reduction in the risk of infection in older children. We also saw a significant decrease in parasite numbers in infants and older children, which is linked to a decrease in risk of clinical disease," Professor Mueller said.

The finding could have dramatic implications for future malaria vaccine design and development, Professor Mueller said. "Studying the mechanisms that cause SAO-positive people to be protected against P. vivax malaria could help us to better understand the mechanics of infection and help us to identify better targets for a malaria vaccine," he said.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Top 9 Reasons Why We Should Practice Kindness
Top 10 Vitamin B12 Foods for Vegetarians - Slideshow
Targeted Screening Program Beneficial for Prostate Cancer Screening
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Malaria-water Malaria Mosquito Diseases Vaccination for Children Fever Top 10 Vaccine Myths Debunked Malaria - Protection Strategies 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Color Blindness Calculator Nutam (400mg) (Piracetam) Find a Doctor Turmeric Powder - Health Benefits, Uses & Side Effects Find a Hospital Diaphragmatic Hernia Calculate Ideal Weight for Infants Indian Medical Journals Blood Pressure Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use