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New Study Offers Hope for HIV and Hepatitis C Patients

by Sheela Philomena on July 19, 2014 at 10:07 PM
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 New Study Offers Hope for HIV and Hepatitis C Patients

A new study says novel hepatitis C drug has shown early promise in patients whose infection with both HIV and hepatitis C has made them traditionally difficult to treat.

Patients were given Gilead Sciences' sofosbuvir, a drug approved for the US market in 2013 that has stirred controversy due to its high price tag -- about $1,000 per pill, along with another well-known drug, ribavirin.

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The study in the Journal of the American Medical Association's (JAMA) July 23/30 issue included just over 220 people who were treated for either 12 or 24 weeks.

Most of the patients -- between 67 percent and 94 percent depending on the type of hepatitis C they had and whether they had ever been treated for it before -- saw their liver disease disappear and stay away for 12 weeks after they stopped treatment.
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The measurement scientists used was known as sustained virologic response (SVR), or what is clinically considered a "cure" of hepatitis C, a serious and often chronic liver disease.

The study ended 12-weeks after treatment ended, so responses beyond that point are unknown.

As many as seven million people worldwide are infected with both human immunodeficiency virus and hepatitis C, according to background information in the article.

Treating both infections is difficult because patients have needed to use interferon for hepatitis C, which interacts poorly with antiretroviral drugs for HIV suppression.

Seven of the 223 in this study discontinued the treatment because of adverse events, most commonly fatigue, insomnia, headache, and nausea.

Researchers noted that the study was not the most rigorous kind. Doctors knew what they were prescribing to patients, and the participants were not randomized to a comparison treatment or placebo.

However, patients "had high rates of sustained HCV virologic response 12 weeks after cessation of therapy," said the study led by Mark Sulkowski of Johns Hopkins University.

"Further studies of this regimen in more diverse populations of coinfected patients are needed."

An accompanying editorial by Michael Saag of the University of Alabama School of Medicine said the drug combination is a "quantum leap forward" in treatment but that its cost remains too high for widespread use.

"When combined with ribavirin, the average wholesale price of a 12-week course of treatment is $94,500 and $189,000 for a 24-week course," he wrote.

"The world simply cannot afford to pay on a 'cost per cure' basis," he added.

"Hopefully, competition among the new products coming to market in the next 18 months will result in substantially lower pricing for the drugs."

Source: AFP
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