The virus found in Chinese horseshoe bats may be poised to infect efficiently in cultured human airway tissues without the need for adaptation.

‘WIV1-CoV virus may never jump to humans, but if it does, it has the potential to seed a new outbreak with significant consequences for both public health and the global economy.’

The work, led by Ralph Baric, Ph.D., professor of epidemiology at UNC's Gillings School of Global Public Health, comes on the heels of two recent high-profile outbreaks - Ebola and Zika - for which there are no vaccines. The two outbreaks combined claimed thousands of lives and cost billions in foregone economic growth. 




"The capacity of this group of viruses to jump into humans is greater than we originally thought," said Vineet Menachery, Ph.D., the study's first author. "While other adaptations may be required to produce an epidemic, several viral strains circulating in bat populations have already overcome the barrier of replication in human cells and suggest reemergence as a distinct possibility."
Baric and Menachery worked with SARS-like coronavirus sequences isolated from Chinese horseshoe bats, where SARS originated. Based on the sequences, they reconstructed the viruses to evaluate their potential to infect human cells and in mice.
They found that the newly identified virus, known as WIV1-CoV, could bind to the same receptors as SARS-CoV. They also showed that the virus readily and efficiently replicated in cultured human airway tissues, suggesting an ability to jump directly to humans.
"To be clear, this virus may never jump to humans, but if it does, WIV1-CoV has the potential to seed a new outbreak with significant consequences for both public health and the global economy," said Vineet, whose work is reported in the Mar. 13, 2016 online version of the Proceedings of the National Academy of Sciences.
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SARS, short for severe acute respiratory syndrome, was first seen in an outbreak in 2002 and resulted in 8,000 cases and nearly 800 deaths. Spread through airborne contact, its onset presents symptoms similar to the flu with a dry cough but can accelerate rapidly to pneumonia, filling the lungs with fluid and putting extreme stress on the body's immune system.
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"This type of work generates information about novel viruses circulating in animal populations and develops resources to help define the threat these pathogens may pose to human populations," Baric said. "It's important to note that it's not an approach that's limited to SARS or SARS-like viruses. It can be applied to other emerging pathogens to helping us prepare for the next emergent virus, whether it be MERS, the Zika virus or something we haven't even heard of yet."
Source-Eurekalert