Novel markers for coronary heart disease (CHD) have been identified, of which one particular oxidized lipid was found to be the most reliable risk marker for CHD.
CHD is the number one cause of death in both men and women. While many risk factors of CHD, such as smoking, high blood pressure, and age, are common among men and women, some metabolic risk factors, such as being diabetic, are more strongly associated with increased risk of CHD in women than in men.
Moderate Workout can Lower Risk of Heart Disease in Women
Spending two and a half hours a week doing light physical activity like brisk walking can lower the risk of heart disease by 25 percent in women under age 50.
Advertisement
‘Oxidized lipid is the most reliable new risk marker for coronary heart disease (CHD), which is not associated with traditional risk markers.’
Tweet it Now
Even though metabolic risk factors seem to be stronger in women, few studies have sought metabolic markers that is, measurable indicators that can be detected in blood samples of CHD in women.
A new study by Brigham and Women's Hospital researchers recently addressed this gap, uncovering a new biomarker for CHD. Their results are published in Circulation.
![History of Kidney Stones Linked With Coronary Heart Disease in Women]( "History of Kidney Stones Linked With Coronary Heart Disease in Women")
A new study reveals that a history of kidney stones has been linked with an increased risk of coronary heart disease (CHD) in women but not in men.
"We were particularly interested in analyzing samples from women to understand some of the mechanisms underlying these risks," said corresponding author Nina P. Paynter, Ph.D., of the Department of Medicine at BWH.
"We found a set of oxidized lipids that are novel markers for CHD, representing a different pathway contributing to CHD than the pathways we have previously considered."
By comparing the metabolic profiles of women with CHD and a control group of women, the researchers were able to identify one particular oxidized lipid as the most reliable new risk marker for CHD.
These results were replicated in a separate cohort of both men and women. Women in the highest quartile of the marker had a 4-fold higher risk of developing CHD in the next several years.
This marker is not associated with traditional risk markers, such as cholesterol levels and hypertension, suggesting that it contributes to CHD through a different pathway than the classical risk prediction markers.
The exact mechanisms by which the identified oxidized lipid is contributing to CHD is unknown, and the researchers hope that future work will help to uncover how this risk marker is involved with CHD on a molecular level.
"Part of the reason that our study is so exciting is because it highlights that by focusing on specific patient groups, such as women, that have been historically underrepresented in these sort of studies, we can uncover new mechanisms may contribute to disease in the entire population," said senior author Kathryn M. Rexrode, MD, MPH, Chief of the Division of Women's Health of the Department of Medicine at BWH.
Source: Eurekalert
History of Kidney Stones Linked With Coronary Heart Disease in Women
A new study reveals that a history of kidney stones has been linked with an increased risk of coronary heart disease (CHD) in women but not in men.
Advertisement
"We were particularly interested in analyzing samples from women to understand some of the mechanisms underlying these risks," said corresponding author Nina P. Paynter, Ph.D., of the Department of Medicine at BWH.
"We found a set of oxidized lipids that are novel markers for CHD, representing a different pathway contributing to CHD than the pathways we have previously considered."
By comparing the metabolic profiles of women with CHD and a control group of women, the researchers were able to identify one particular oxidized lipid as the most reliable new risk marker for CHD.
These results were replicated in a separate cohort of both men and women. Women in the highest quartile of the marker had a 4-fold higher risk of developing CHD in the next several years.
This marker is not associated with traditional risk markers, such as cholesterol levels and hypertension, suggesting that it contributes to CHD through a different pathway than the classical risk prediction markers.
The exact mechanisms by which the identified oxidized lipid is contributing to CHD is unknown, and the researchers hope that future work will help to uncover how this risk marker is involved with CHD on a molecular level.
"Part of the reason that our study is so exciting is because it highlights that by focusing on specific patient groups, such as women, that have been historically underrepresented in these sort of studies, we can uncover new mechanisms may contribute to disease in the entire population," said senior author Kathryn M. Rexrode, MD, MPH, Chief of the Division of Women's Health of the Department of Medicine at BWH.
Source: Eurekalert
High Risk of Heart Disease In Women With Post traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a psychological disorder that develops after a traumatic event, symptoms include flashback, insomnia and emotional numbness.
Advertisement
 6 Healthy Lifestyle Choices can Help Prevent Heart Disease in WomenFollowing 6 healthy lifestyle choices can help prevent heart disease in nearly 3 out of 4 women. | Advertisement
|
Advertisement
Recommended Reading
Latest Heart Disease News
The first community-based study, published in the journal Lancet, says that delays in seeking care account for nearly 55% of the reported cardiac and stroke deaths in India.
The study emphasizes the existing proof on the heart disease risks of tobacco smoking and the urgent need to stop smoking among cancer survivors.
New study findings provide novel pathophysiological insights involving blood vessel integrity and tissue-mediated coagulation in a type of heart attack in young women.
Recent study identifies five heart failure subtypes with the potential for individual patient risk prediction.
In middle-age patients, CT scan identifies people who may benefit from drugs to decrease heart disease risk, stated study.