About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Risk Index To Identify Those With Opioid Overdose

by Julia Samuel on April 17, 2017 at 5:22 PM
Font : A-A+

New Risk Index To Identify Those With Opioid Overdose

The risk of serious prescription opioid overdose is high among individuals suffering from a substance use disorder (SUD) or depression, according to a study published in Pain Medicine.

The retrospective, case-control study analyzed and compared patients with an opioid prescription from two health care claims databases: the U.S. Veterans Health Administration (VHA) from 2010-12 (1.9 million patients) and a U.S. commercial health plan database (IMS PharMetrics Plus) from 2009-13 (18.3 million patients).

Advertisement


Risk factors for overdose in the 7,234 overdose cases in the commercially insured population (CIP) were analyzed and compared with the risk factor profile for the 718 VHA overdose cases. This is the most comprehensive characterization and comparison published to date of U.S. medical users of prescription opioids and overdose cases.

The strongest risk factors for prescription opioid overdose in the CIP were diagnosed depression and SUD of any type -- not just opioid dependence, abuse or addiction. Other strongly associated factors included other mental health disorders; impaired liver, kidney, vascular or lung function; and non-cancer pancreatic disease.
Advertisement

A high total daily opioid dose, certain opioids and extended-release or long-acting opioids also were strong predictors of overdose. Taking certain other medications that affect the mind or behavior, such as benzodiazepines or antidepressants, increased an opioid user's risk of overdose.

The risk factor profiles largely were similar between the two populations despite substantial population differences in demographics, pre-existing health conditions, current medications, recent emergency department visits and hospitalizations, as well as differences between the public and private health care systems including medication-prescribing practices and drug formularies.

There was considerably greater prescribing prevalence of higher total daily opioid doses, all opioids except morphine and methadone, and most non-opioid medications, including psychoactive drugs, in the CIP overall than in the VHA population. However, extended-release or long-acting opioids were prescribed only about half as frequently among overdose cases in the CIP as in VHA.

Pain management is complex and multidimensional, and the risk of an opioid overdose is dependent on multiple factors.

"Any treatment plan involving opioids requires an individualized approach due to the potential for a serious overdose in all patients, regardless of age or indication," said Barbara Zedler, M.D., senior author and chief medical officer of Venebio, a life sciences consultancy.

"Safe and appropriate opioid prescribing requires a personalized approach that accounts for a patient's demographic and psychosocial characteristics, active clinical conditions, other medications and substances used, and opioid-specific characteristics."

Venebio is the developer of the only validated opioid risk index and clinical decision support tool available -- Venebio Opioid Advisor (VOA) calculates a patient's likelihood of a life-threatening overdose from a prescription opioid.

It also determines their personalized risk factor profile and gives individualized guidance regarding interventions that health care professionals can consider to reduce the patient's risk of overdose. Ongoing development of VOA is supported by a $1.5-million grant from the National Institute on Drug Abuse of the National Institutes of Health.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cannabis Drug Abuse Drug Detox Painkiller Addiction 

Recommended Reading
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or ......
Alcohol Addiction and Women
Social drinking amongst women has become a fad. Stop it before it finishes you....
Painkiller Addiction
Painkiller addiction is the use of prescription painkillers in a way not meant by the prescribing .....
Caffeine and Decaffeination
Caffeine is a psychoactive stimulant alkaloid commonly found in many of the products we consume ......
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Drug Detox
Drug detoxification (or drug detox) is a process that helps drug addicts to give up drugs with less ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)